Penetration of topically administered ofloxacin and trimethoprim into aqueous humor
Penetration of topically administered ofloxacin and trimethoprim into aqueous humor
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DOI：
10.1089/10807680260362722
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发表时间：
2002-10-01
影响因子：
2.3
通讯作者：
Zeh, W
中科院分区：
文献类型：
--
作者：
Price, FW;Dobbins, K;Zeh, W
在计划进行白内障手术的成年志愿者中评估了两种用于治疗细菌性结膜炎的局部抗生素的眼部渗透性。在这项随机、平行组研究中，患者每日一次滴注 0.1% 硫酸甲氧苄啶/多粘菌素 B (n = 23) 或 0.3% 氧氟沙星 (n = 25)，持续 3 天，并在手术前一小时滴注 4 次。对手术期间获得的房水样本的分析显示，氧氟沙星的浓度是甲氧苄啶的 2.4 倍（1.135 微克/毫升 vs 0.470 微克/毫升；P < .0001）。氧氟沙星在眼组织中的浓度较高，加上其卓越的抗菌活性，支持其作为甲氧苄啶/多粘菌素 B 的替代品用于治疗细菌性结膜炎。
Ocular penetration of two topical antibiotics used to treat bacterial conjunctivitis was assessed in adult volunteers scheduled for cataract surgery. In this randomized, parallel-group study, patients instilled trimethoprim sulfate 0.1%/polymyxin B (n = 23) or ofloxacin 0.3% (n = 25) QID for 3 days, plus 4 instillations in the hour before surgery. Analysis of aqueous humor samples obtained during surgery showed a 2.4-fold greater concentration of ofloxacin over trimethoprim (1.135 mug/ml vs 0.470 mug/ml; P < .0001). The greater concentration of ofloxacin in ocular tissue coupled with its superior antibacterial activity profile supports its use as an alternative to trimethoprim/polymyxin B for treatment of bacterial conjunctivitis.