Spatio-temporal Pattern Formation due to Host-Circuit Interplay in Gene Expression Dynamics
Spatio-temporal Pattern Formation due to Host-Circuit Interplay in Gene Expression Dynamics
复制标题
基因表达动力学中宿主电路相互作用导致的时空模式形成
DOI：
10.1016/j.chaos.2022.112995
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Sayantari Ghosh
中科院分区：
文献类型：
--
作者：
Priyanka Chakraborty;M. Jolly;U. Roy;Sayantari Ghosh
生物系统主要依赖于它们的双稳态性质，以便在细胞形态和生理方面表现出非遗传异质性。表型异质性细胞的空间格局，由于潜在的双稳态，可能会发挥重要作用的现象，如生物膜的发展，适应，细胞运动等，而非线性正反馈调节，如合作异源二聚体的形成是背后的双稳态的通常原因，类似的动态也可以发生作为主机电路相互作用的结果。在本文中，我们已经调查了图案形成的模体与非合作的正反馈，施加代谢负担，其主机由于其表达。在扩散环境中的细胞阵列中，我们分别研究了不同初始条件下一维和二维的硅时空扩散。此外，表现出相同的稳定状态的细胞的数量，以及它们的空间分布已被量化的连接组件分析。扩散系数的变化的影响进行了研究的相关状态的稳定性和时间演化的模式。
Biological systems are majorly dependent on their property of bistability in order to exhibit nongenetic heterogeneity in terms of cellular morphology and physiology. Spatial patterns of phenotypically heterogeneous cells, arising due to underlying bistability, may play significant role in phenomena like biofilm development, adaptation, cell motility etc. While nonlinear positive feedback regulation, like cooperative heterodimer formation are the usual reason behind bistability, similar dynamics can also occur as a consequence of host-circuit interaction. In this paper, we have investigated the pattern formation by a motif with non-cooperative positive feedback, that imposes a metabolic burden on its host due to its expression. In a cellular array set inside diffusible environment, we investigatein-silicospatio-temporal diffusion in one dimension as well as in two dimension in the context of various initial conditions respectively. Moreover, the number of cells exhibiting the same steady state, as well as their spatial distribution has been quantified in terms of connected component analysis. The effect of diffusion coefficient variation has been studied in terms of stability of related states and time evolution of patterns.
影响因子：
4.3
作者：
通讯作者：
--
影响因子：
14.8
作者：
Tan, Cheemeng;Marguet, Philippe;You, Lingchong
通讯作者：
You, Lingchong