Lesional expression of the endogenous angiogenesis inhibitor endostatin/collagen XVIII following traumatic brain injury (TBI)
Lesional expression of the endogenous angiogenesis inhibitor endostatin/collagen XVIII following traumatic brain injury (TBI)
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DOI：
10.1016/j.expneurol.2007.07.020
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发表时间：
2007-12-01
影响因子：
5.3
通讯作者：
Schwab, J. M.
中科院分区：
文献类型：
--
作者：
Mueller, C. A.;Schluesener, H. J.;Schwab, J. M.
我们分析了刺伤损伤后内源性血管生成抑制剂内皮抑制素/胶原XVIII的表达，并观察到局限于全坏死损伤和继发性损伤区域的高度显著性（p < 0.0001）损伤累积。在第14天检测到最大细胞数，直到损伤后第21天才下降。此外，内皮抑制素/胶原蛋白XVIII+单核细胞在Virchow-Robin间隙中积累，在那里它们形成细胞簇。内皮抑素/胶原XVIII表达除了明显定位于ED 1（+）激活的小胶质细胞/巨噬细胞外，还可在病变区域的内皮下周围血管中检测到。内皮抑制素/胶原蛋白XVIII+小胶质细胞/巨噬细胞的晚期和长期积累以及血管修剪和退化区域中内皮抑制素/胶原蛋白XVIII+内皮下细胞/血管数量的增加，表明与“晚期”炎症环境相关的瞬时血管生成反应终止中的作用。(c)2007年爱思唯尔公司All rights reserved.
We have analysed the expression of the endogenous angiogenesis inhibitor endostatin/collagen XVIII following stab wound injury and observed a highly significant (p < 0.0001) lesional accumulation confined to areas of pan-necrotic injury and developing secondary damage. Maximal cell numbers were detected at Day 14, declining until Day 21 after injury. Further, endostatin/collagen XVIII+ monocytic cells accumulated in Virchow-Robin spaces where they formed cell clusters. Besides being prevailingly localised to ED1(+) activated microglia/macrophages, endostatin/collagen XVIII expression was also detected by subendothelial surrounding vessels in the lesioned area. Late and prolonged accumulation of endostatin/collagen XVIII+ microglia/macrophages and increased numbers of endostatin/collagen XVIII+ subendothelial cells/vessels in areas of vascular pruning and regression, point to a role in the termination of the transient angiogenic response, linked to a "late" inflammatory milieu. (c) 2007 Elsevier Inc. All rights reserved.