Magnetic resonance spectroscopy:: an in vivo tool for monitoring cerebral injury in SIV-infected macaques
Magnetic resonance spectroscopy:: an in vivo tool for monitoring cerebral injury in SIV-infected macaques
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DOI：
10.1034/j.1600-0684.2002.02009.x
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发表时间：
2002-08-01
影响因子：
0.7
通讯作者：
Gonzalez, RG
中科院分区：
文献类型：
--
作者：
Greco, JB;Sakaie, KE;Gonzalez, RG
本研究的目的是证明利用体内质子磁共振波谱（MRS）监测艾滋病猕猴模型SIV感染的脑表现的可行性。回顾了以往在猕猴脑组织和人体体内的光谱工作，为本研究提供了动机和背景。我们收集了14只未感染的恒河猴的34组MRS数据。从这些数据中，我们证明我们能够在少于10只动物的情况下检测到与人类MRS研究中观察到的大多数代谢物相似的变化。在这项研究中使用的幼年猕猴显示出n -乙酰天冬氨酸（NAA）水平的年龄相关变化，这是一种神经元标志物。研究发现，猕猴体内神经化学物质的数量和分布与人类略有不同，但差异很大。
The purpose of our study was to demonstrate the feasibility of using in vivo proton Magnetic Resonance Spectroscopy (MRS) to monitor the brain manifestations of SIV infection in the macaque model of AIDS. Previous spectroscopy work on macaque brain tissue and in vivo work in humans is reviewed to provide the motivation and context for this study. We collected 34 MRS data sets on 14 uninfected rhesus macaques. From this data, we demonstrate that we are capable of detecting changes similar to those observed in human MRS studies for most metabolites using less than 10 animals. The juvenile macaques utilized in this study demonstrate age-related changes in the levels of N-acetyl aspartate (NAA), a neuronal marker. The quantity and distribution of neurocheMicals in the macaque are found to be slightly, but significantly, different than in the human.