Cortisol level measurements in fingernails as a retrospective index of hormone production
Cortisol level measurements in fingernails as a retrospective index of hormone production
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DOI：
10.1016/j.psyneuen.2015.01.015
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发表时间：
2015-04-01
影响因子：
3.7
通讯作者：
Togo, Fumiharu
中科院分区：
文献类型：
--
作者：
Izawa, Shuhei;Miki, Keiichi;Togo, Fumiharu
指甲中的皮质醇水平可能反映了荷尔蒙在很长一段时间内的累积产量，但这些概念还没有完全确立。在这项研究中，我们研究了指甲中的皮质醇与较长时期(头发皮质醇)和相对较短时期(唾液皮质醇)皮质醇积累的关系。研究一采集了58名中老年男性的头发和指甲样本。头发皮质醇水平与指甲皮质醇水平呈中度正相关(r=0.29，p<；0.05和r(5)=0.36，p<；0.01)。在研究2中，37名工人在一天的过程中(醒来时、醒来后30分钟、午餐前和工作后)提供了4份唾液样本，并在一个月后提供了另一组唾液样本。此外，这些工人被要求在六个月的时间里提供指甲样本。我们发现，唾液中的皮质醇水平(皮质醇曲线下面积)与4个月和5个月后采集的指甲样本中的皮质醇水平呈中度相关(r=0.43，p<；0.05和r(S)=0.5，p<；0.01；r=0.45，p<；0.05和r(S)=0.53，p<；0.01)。这些结果表明，指甲样本中的皮质醇水平可能在一定时期内反映了激素的产生。指甲样本中的皮质醇水平可能有助于研究心理社会压力与健康之间的联系。(C)2015爱思唯尔有限公司。保留所有权利。
The cortisol Level in fingernails may reflect the hormone's cumulative production over a long period, but the notions have not been fully established. In this study, we investigated the association of cortisol in fingernails with cortisol accumulation over a long period (hair cortisol) and over a relatively short period (salivary cortisol). In study 1, hair and fingernail samples were collected from 58 middle-aged and elderly men. The cortisol level in hair samples was moderately associated with the level in fingernail samples (r=0.29, p < 0.05 and r(5)=0.36, p < 0.01). In study 2, 37 workers provided 4 saliva samples over the course of one day (at awakening, 30 min after awakening, before lunch, and after work) and another set a month later. Further, the workers were asked to provide fingernail samples during a six-month period. We found that the cortisol level in saliva over the whole day (area under the curve for cortisol) was moderately associated with the cortisol level measured in fingernail samples that were collected 4 months (r=0.43, p < 0.05 and r(s)=0.50, p < 0.01) and 5 months later (r=0.45, p < 0.05 and r(s)=0.53, p < 0.01). These results indicated that the cortisol level in fingernail samples might retrospectively represent hormone production during a given period. The cortisol level in fingernail samples may be useful in the investigation of the link between psychosocial stress and health. (C) 2015 Elsevier Ltd. All rights reserved.