Effects of varying duty cycle and pulse width on high-intensity focused ultrasound (HIFU)-induced transcranial thrombolysis.
Effects of varying duty cycle and pulse width on high-intensity focused ultrasound (HIFU)-induced transcranial thrombolysis.
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DOI：
10.1186/2050-5736-1-18
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Voie A
中科院分区：
文献类型：
--
作者：
Hölscher T;Raman R;Fisher DJ;Ahadi G;Zadicario E;Voie A
目的是通过体外血流模型测试脉冲宽度（PW）和占空比（DC）的不同组合对高强度聚焦超声（HIFU）诱导的超声溶栓效果的影响。使用ExAblate™4000 HIFU头部系统（InSightec公司，以色列）。人造血凝块被放入人类颅骨内的试管中，并暴露在脉动流中。针对四种不同的脉冲宽度测试了四种不同的占空比。在所有研究组中，溶栓疗效的提高与DC和/或PW的增加相关（p < 0.0001）。使用经颅HIFU，可以在几秒钟内实现明显的溶栓，而无需体外使用溶栓药物。较长的占空比与较长的脉冲宽度相结合，似乎具有最大的潜力，以优化凝块溶解功效。
The goal was to test the effects of various combinations of pulse widths (PW) and duty cycles (DC) on high-intensity focused ultrasound (HIFU)-induced sonothrombolysis efficacy using an in vitro flow model. An ExAblate™ 4000 HIFU headsystem (InSightec, Inc., Israel) was used. Artificial blood clots were placed into test tubes inside a human calvarium and exposed to pulsatile flow. Four different duty cycles were tested against four different pulse widths. For all study groups, an increase in thrombolysis efficacy could be seen in association with increasing DC and/or PW (p < 0.0001). Using transcranial HIFU, significant thrombolysis can be achieved within seconds and without the use of lytic drugs in vitro. Longer duty cycles in combination with longer pulse widths seem to have the highest potential to optimize clot lysis efficacy.