Gray matter volume alterations in first-episode drug-naïve patients with deficit and nondeficit schizophrenia.
Gray matter volume alterations in first-episode drug-naïve patients with deficit and nondeficit schizophrenia.
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DOI：
10.1016/j.pscychresns.2015.09.015
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发表时间：
2015-11-30
影响因子：
11.3
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Lei W;Deng W;Li M;He Z;Han Y;Huang C;Ma X;Wang Q;Guo W;Li Y;Jiang L;Gong Q;Hu X;Zhang N;Li T
据报道，相对于非缺陷型精神分裂症（NDS）患者，缺陷型精神分裂症（DS）慢性患者的灰质体积（GMV）异常模式不同。然而，尚不清楚这些差异是否是DS病理生理学的特征，还是由于药物或疾病持续时间的影响。为了解决这一问题，使用基于体素的形态测量法（VBM）评估了88例首次发作、药物初治的精神分裂症患者（44例DS和44例NDS）、67例一级亲属和84例健康对照的GMV，并进行了组间比较。GMV与患者临床症状的相关性也进行了评估。与对照组相比，DS患者显示更严重的GMV减少小脑穹隆比NDS患者。在DS（但不是NDS）患者的一级亲属中也观察到GMV降低，这表明DS和NDS可能存在不同的遗传风险。DS患者的左丘脑明显小于NDS患者和对照组，并且该区域较小的GMV与患者更严重的阴性症状相关。我们的研究结果共同表明，DS可能代表了一个不同的亚型精神分裂症从NDS和GMV的变化，在左额肌可能是一个形态学签名的DS。
Different patterns of gray matter volume (GMV) abnormalities have been reported between chronic patients with deficit schizophrenia (DS), relative to nondeficit schizophrenia (NDS) patients. However, it is not clear whether these differences are characteristic to the pathophysiology of DS or due to the effects of medications or illness durations. To address this issue, GMV in 88 first-episode, drug-naive patients with schizophrenia (44 DS and 44 NDS), 67 of their first-degree relatives and 84 healthy controls were assessed using voxel- based morphometry (VBM) and compared between groups. Correlations between GMV and clinical symptoms in patients were also assessed. Compared to controls, DS patients displayed more severe GMV reduction in the cerebellar culmen than NDS patients. GMV reduction in culmen was also observed in the first-degree relatives of DS (but not NDS) patients, suggesting possible different genetic risk in DS and NDS. The left insula was significantly smaller in DS patients than both NDS patients and controls, and smaller GMV of this region was associated with more severe negative symptoms in patients. Our results collectively indicate that DS might represent a distinct subtype of schizophrenia from NDS and the GMV change in left insula may be a morphological signature of DS.