Terminal deoxynucleotidyl transferase‐positive acute myeloblastic leukemia
Terminal deoxynucleotidyl transferase‐positive acute myeloblastic leukemia
复制标题
末端脱氧核苷酸转移酶阳性急性髓细胞白血病
DOI：
10.1002/ajh.2830100304
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发表时间：
1981
影响因子：
12.8
通讯作者：
S. Stass
中科院分区：
文献类型：
--
作者：
T. McGraw;J. Folds;F. Bollum;S. Stass;S. Stass
末端脱氧核苷酸转移酶(TdT)是急性淋巴细胞白血病(ALL)的生化标志物。在初诊ALL的研究中，间接免疫荧光检测的TDT阳性细胞通常大于40%，而急性髓细胞白血病(AML)的TDT阳性细胞不到1%。罕见的TDT阳性AML病例已有报道。我们在这里介绍了三名AML患者，在15%、45%和90%的白血病原始细胞中有TDT。AML的诊断建立在形态学和细胞化学的基础上，其中包括1例AUER棒患者。髓过氧化物酶分别在20%、90%和5%的原始细胞中表达。这三个病例中都没有费城染色体。这些结果可能表明同时存在淋巴系和髓系群体，或同时存在具有淋巴系和髓系标志的原始细胞。
Terminal deoxynucleotidyl transferase (TdT) is a biochemical marker for acute lymphoblastic leukemia (ALL). In studies of ALL at diagnosis, there are usually greater than 40% TdT‐positive cells by indirect immunofluorescence, whereas acute myeloblastic leukemia (AML) shows less than 1% TdT‐positive cells. Rare cases of TdT‐positive AML have been reported. We present here three AML patients with TdT in 15%, 45%, and 90% of the leukemic blasts. The diagnosis of AML was established on the basis of morphology and cytochemistry, and the cases included one patient with Auer rods. Myeloperoxidase was present respectively in 20%, 90%, and 5% of the blasts. There was no Philadelphia chromosome present in the three cases. These results may indicate the simultaneous presence of lymphoid and myeloid populations, or the presence of a blast cell with both lymphoid and myeloid markers.