Targeting DNA repair pathways for cancer treatment: what's new?
Targeting DNA repair pathways for cancer treatment: what's new?
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DOI：
10.2217/fon.14.60
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Fishel ML
中科院分区：
文献类型：
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作者：
Kelley MR;Logsdon D;Fishel ML
DNA修复途径的中断使细胞易于积累DNA损伤。越来越多的证据表明，随着癌症的进展，肿瘤在DNA修复蛋白中积累了越来越多的突变。DNA修复机制极大地影响了对细胞毒性治疗的反应，因此了解这些机制并找到方法将失调的修复过程转化为自身诱导肿瘤死亡是所有DNA修复抑制努力的目标。抑制可以是直接的或间接的。这个新兴的研究领域充满了希望和挑战，因为发现了每个修复途径的更多复杂性。在一个越来越关注医疗成本的时代，使用DNA修复抑制剂可以证明是对研发资源和患者费用的高效管理。
Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A growing body of evidence indicates that tumors accumulate progressively more mutations in DNA repair proteins as cancers progress. DNA repair mechanisms greatly affect the response to cytotoxic treatments, so understanding those mechanisms and finding ways to turn dysregulated repair processes against themselves to induce tumor death is the goal of all DNA repair inhibition efforts. Inhibition may be direct or indirect. This burgeoning field of research is replete with promise and challenge, as more intricacies of each repair pathway are discovered. In an era of increasing concern about healthcare costs, use of DNA repair inhibitors can prove to be highly effective stewardship of R&D resources and patient expenses.