Large nonlinear effect observed in the enantiomeric excess of proline in solution and that in the solid state
Large nonlinear effect observed in the enantiomeric excess of proline in solution and that in the solid state
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DOI：
10.1002/anie.200601506
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Koshino, Hiroyuki
中科院分区：
文献类型：
--
作者：
Hayashi, Yujiro;Matsuzawa, Masayoshi;Koshino, Hiroyuki
纯手性氨基酸和糖是如何从假定的前手性益生元环境中产生的是一个令人困惑的问题，[1]对此已经提出了许多答案：例如，圆偏振光的绝对不对称合成，手性晶体中的光反应，以及不对称自催化的不对称自动倍增，如Soai等人最近的工作所示。[2]有报道描述了氨基酸和糖的手性之间的联系：在使用脯氨酸作为催化剂的醛的α氨氧基化中观察到ee的扩增，以产生糖的关键中间体，而氨基酸
How homochiral amino acids and sugars arose out of a presumably prochiral prebiotic environment is a puzzling question,[1] to which many answers have been proposed: for example, absolute asymmetric synthesis with circularly polarized light, photoreactions in chiral crystals, and asymmetric automultiplication with asymmetric autocatalysis, as exemplified by the recent work of Soai et al.[2] There are reports describing a connection between the chirality of amino acids and sugars: Amplification of ee was observed in the αaminoxylation of an aldehyde using proline as catalyst to generate a key intermediate of sugars,[3] while amino acids