Clinical significance of Gaucher cells in cerebrospinal fluid
Clinical significance of Gaucher cells in cerebrospinal fluid
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脑脊液中戈谢细胞的临床意义
DOI：
10.1111/j.1651-2227.1999.tb01280.x
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发表时间：
1999
期刊：
影响因子：
3.8
通讯作者：
A. Fujita
中科院分区：
文献类型：
--
作者：
N. Sakura;N. Mizoguchi;H. Ueda;A. Fujita
4 vs 6.9 3.7, p< 0.001；滑上皮褶13.6 6.5 vs 7.9 5, p< 0.001)。青春期前女孩平均血清瘦素浓度为2.52 2.11 ng ml ÿ1，低于青春期女孩（4.44 3.58 ng ml ÿ1; p< 0.001）。对于联合组（青春期前和青春期女孩），血清瘦素浓度与体重（r = 0.53;p< 0.001）、BMI （r = 0.58;p< 0.001）、肱三头肌皮褶（r = 0.53;p< 0.001）、肩胛下皮褶（r = 0.62; p< 0.001）和滑膜上皮褶（r = 0.60;p< 0.001）相关。瘦素浓度稳步上升，与体重指数和身体各部位脂肪厚度的增加平行；然而，肩胛下脂肪厚度与瘦素浓度之间的相关性最好（表2）。这些数据与Hassink等人(3)发表的数据相似，他们发现瘦素与BMI之间存在很强的相关性，在一组儿童（肥胖和正常体重）中瘦素与手臂脂肪之间也存在很强的相关性。此外，与肥胖无关的瘦素浓度随着Tanner阶段的变化而变化。据推测，儿童表现出相对的“瘦素抵抗”，以支持其生殖能力的增长和发展。在我们的数据中，手臂脂肪厚度也与瘦素浓度密切相关（r = 0.54），但这种相关性略弱于肩胛下脂肪厚度。适当的营养状况对青春期开始的影响在一个理论中得到了表达，该理论将临界体重与下丘脑-垂体-性腺轴的激活联系起来(4)。由于瘦素受体存在于下丘脑和大脑的其他部位(5)，以及卵巢(6)，并且ob/ob小鼠的外源性瘦素治疗逆转了它们的肥胖并恢复了生育能力，因此ob基因的产物(1)是一个可行的候选者，作为允许青春期继续进行的许可信号。在我们的研究中，我们已经清楚地表明，血清瘦素浓度与身体各个区域的皮肤褶皱厚度以及BMI有很强的相关性，因此我们可以得出结论，瘦素是青春期女孩营养状况的一个很好的生化指标。
4 vs 6.9 3.7, p< 0.001; suprailiac skinfold 13.6 6.5 vs 7.9 5, p< 0.001). In prepubertal girls the mean serum leptin concentration was 2.52 2.11 ng ml ÿ1, which was lower than in pubertal girls (4.44 3.58 ng ml ÿ1; p< 0.001). For the combined group (prepubertal and pubertal girls), the serum leptin concentration was correlated with body weight (r = 0.53;p< 0.001), BMI (r = 0.58;p< 0.001), triceps skinfold ( r = 0.53;p< 0.001), subscapular skinfold (r = 0.62; p< 0.001) and suprailiac skinfold (r = 0.60;p< 0.001) measurements. A steady increase in leptin concentration was seen, parallel to the increase in BMI and the thickness of the fat in various regions of the body; however, the best correlation was found between the subscapular fat thickness and leptin concentration (Table 2). These data are similar to those published by Hassink et al (3), who found a strong correlation between leptin and the BMI as well as between leptin and arm fat in a combined group of children (obese and normal weight). Moreover, leptin concentrations, independent of adiposity, were found to vary with the Tanner stage. It has been hypothesized (3) that children manifest a relative “leptin resistance” to support increased growth and development of their reproductive capacity. In our data the arm fat thickness also correlated closely with leptin concentration ( r = 0.54), but this correlation was slightly weaker than that with subscapular fat thickness. The influence of proper nutritional status on the onset of puberty was expressed in a theory that links the critical body mass to the activation of the hypothalamic–pituitary–gonadal axis (4). Since leptin receptors are found in the hypothalamus and other parts of the brain (5), as well as in the ovary (6), and the exogenous leptin treatment of ob/ob mice reverses their obesity and restores fertility, the product of the ob gene (1) is a viable candidate as a permissive signal that allows puberty to proceed. In our study we have clearly shown that serum leptin concentration correlates strongly with the thickness of the skinfolds in various regions of the body as well as with the BMI, and therefore we can conclude that leptin is a very good biochemical marker of nutritional status in girls during puberty.