OMEGA-3-FATTY-ACIDS - ESSENTIAL FATTY-ACIDS WITH IMPORTANT BIOLOGICAL EFFECTS, AND SERUM PHOSPHOLIPID FATTY-ACIDS AS MARKERS OF DIETARY OMEGA-3-FATTY-ACID INTAKE
OMEGA-3-FATTY-ACIDS - ESSENTIAL FATTY-ACIDS WITH IMPORTANT BIOLOGICAL EFFECTS, AND SERUM PHOSPHOLIPID FATTY-ACIDS AS MARKERS OF DIETARY OMEGA-3-FATTY-ACID INTAKE
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DOI：
10.1093/ajcn/57.5.801s
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发表时间：
1993-05-01
影响因子：
7.1
通讯作者：
VIK, T
中科院分区：
文献类型：
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作者：
BJERVE, KS;BRUBAKK, AM;VIK, T
血清磷脂二十碳五烯酸 (PL-EPA) 和二十二碳六烯酸 (PL-DHA) 浓度与膳食中 omega3 脂肪酸的摄入量相关。 211 名糖尿病患者中相隔 4 年测量的 PL-EPA 和 PL-DHA 浓度高度相关，Spearman 相关系数分别为 0.49 (p = 0.0001) 和 0.64 (p = 0.0001)。 PL-DHA 与早产儿贝利精神运动和心理发育指数（分别为 PDI 和 MDI）呈正相关。使用多重回归分析，64%（R2 = 0.639；p = 0.0001）的 PDI 方差由 1/DHA 和 1 年体重解释，而 82%（R2 = 0.816；p = 0.0001）MDI 方差由 1 年体重、Apgar 评分、1/DHA 和 1/EPA 解释。 1/DHA与PDI和MDI呈负相关，而1/EPA与MDI呈正相关。结果表明，婴儿配方奶粉应含有预先形成的 DHA，并且除了 DHA 之外，过多的 EPA 供应可能对早产儿有害。
Serum phospholipid eicosapentaenoic (PL-EPA) and docosahexaenoic acid (PL-DHA) concentrations are associated with the dietary intake of omega3 fatty acids. PL-EPA and PL-DHA concentrations measured 4 y apart in 211 diabetic patients were highly correlated, with Spearman correlation coefficients of 0.49 (p = 0.0001) and 0.64 (p = 0.0001), respectively. PL-DHA was positively associated with Bayley psychomotor and mental developmental indexes (PDI and MDI, respectively) in preterm infants. Using multiple-regression analysis, 64% (R2 = 0.639; p = 0,0001) of PDI variance was explained by 1/DHA and weight at 1 y, whereas 82% (R2 = 0.816; p = 0.0001) of MDI variance was explained by weight at 1 y, Apgar score, 1/DHA, and 1/EPA. 1/DHA was negatively correlated with PDI and MDI, whereas 1/EPA was positively correlated with MDI. The results suggest that infant formulas should contain preformed DHA, and that a too-high supply of EPA in addition to DHA might be harmful in preterm infants.