Use of sodium bicarbonate to promote weight gain, maintain body temperature, normalize renal functions and minimize mortality in rodents receiving the chemotherapeutic agent cisplatin.
Use of sodium bicarbonate to promote weight gain, maintain body temperature, normalize renal functions and minimize mortality in rodents receiving the chemotherapeutic agent cisplatin.
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DOI：
10.1016/j.neulet.2013.03.033
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发表时间：
2013-06-07
影响因子：
2.5
通讯作者：
Hohmann AG
中科院分区：
文献类型：
--
作者：
Guindon J;Hohmann AG
描述了一种减少化疗药物顺铂对动物健康不利影响的简单方法。皮下注射生理盐水 (0.9% NaCl) 的动物在每周注射一次顺铂（腹腔注射 3 mg/kg × 3 或 4 周）之前，患者表现出体重增加失败、体温降低、肌酐和酮水平升高以及肾重量比增加。相比之下，在顺铂（3 mg/kg i.p.×3 或 4 周）之前用碳酸氢钠（4% NaHCO3 生理盐水）治疗的大鼠表现出正常的体重增加、体温、肌酐和酮水平以及正常的肾脏重量比（分别超过 16 或 28 天）。顺铂引起的神经病变（即机械性和冷性异常性疼痛）在两组中发生的情况相同。我们的研究表明，NaHCO3 预处理可促进动物健康，并防止重复顺铂治疗后体重减轻、体温失调和肾毒性迹象（即肌酐和肾脏重量比增加），而不会改变化疗引起的周围神经病变的发展。
A simple method to reduce adverse effects of the chemotherapeutic agent cisplatin on animal health is described. Animals receiving normal saline (0.9% NaCl) s.c. prior to once weekly injections of cisplatin (3 mg/kg i.p.×3 or 4 weeks) exhibited failure of weight gain, lowered body temperature, elevations in creatinine and ketone levels and increased kidney weight ratios. By contrast, rats treated with sodium bicarbonate (4% NaHCO3 in saline s.c.) prior to cisplatin (3 mg/kg i.p.×3 or 4 weeks) exhibited normal weight gain, body temperature, creatinine and ketone levels, as well as normal kidney weight ratios (over 16 or 28 days, respectively). Cisplatin-induced neuropathy (i.e. mechanical and cold allodynia) developed equivalently in both groups. Our studies suggest that NaHCO3 pretreatment promotes animal health and prevents weight loss, body temperature dysregulation and signs of renal toxicity (i.e. increases in creatinine and kidney weight ratio) following repeated cisplatin treatment without altering the development of chemotherapy-induced peripheral neuropathy.
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影响因子：
6.1
作者：
Do Amaral, Catia Lira;Francescato, Heloisa Della Coletta;Pires Bianchi, Maria De Lourdes
通讯作者：
Pires Bianchi, Maria De Lourdes
影响因子：
19.6
作者：
Kishore, BK;Krane, CM;Cacini, W
通讯作者：
Cacini, W
影响因子：
2.7
作者：
Vera, Gema;Chiarlone, Anna;Abalo, Raquel
通讯作者：
Abalo, Raquel
影响因子：
4.2
作者：
ASKEW, EW;DOHM, GL;HUSTON, RL
通讯作者：
HUSTON, RL
影响因子：
3
作者：
Mir, Olivier;Ropert, Stanislas;Goldwasser, Francois
通讯作者：
Goldwasser, Francois