Modeling the mechanics of cancer: effect of changes in cellular and extra-cellular mechanical properties.
Modeling the mechanics of cancer: effect of changes in cellular and extra-cellular mechanical properties.
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DOI：
10.3389/fonc.2013.00145
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发表时间：
2013
影响因子：
4.7
通讯作者：
Zaman MH
中科院分区：
文献类型：
--
作者：
Katira P;Bonnecaze RT;Zaman MH
恶性转化虽然主要由细胞中的基因突变驱动，但也伴随着细胞和细胞外机械性质的特定变化，例如硬度和粘附性。当转化的细胞生长成肿瘤时，它们通过物理接触和施加力与周围环境相互作用。这些力可以导致基于细胞及其周围环境的机械特性的细胞命运的机械调节的变化。全面了解癌症进展需要研究肿瘤生长和转移过程中机械特性的特定变化如何影响集体细胞行为。在这里，我们回顾了一些关键的结果，从计算模型描述的细胞和细胞外的机械性能的变化的影响，并确定癌症进展的机制途径，可以有针对性的预测，治疗和预防癌症。
Malignant transformation, though primarily driven by genetic mutations in cells, is also accompanied by specific changes in cellular and extra-cellular mechanical properties such as stiffness and adhesivity. As the transformed cells grow into tumors, they interact with their surroundings via physical contacts and the application of forces. These forces can lead to changes in the mechanical regulation of cell fate based on the mechanical properties of the cells and their surrounding environment. A comprehensive understanding of cancer progression requires the study of how specific changes in mechanical properties influences collective cell behavior during tumor growth and metastasis. Here we review some key results from computational models describing the effect of changes in cellular and extra-cellular mechanical properties and identify mechanistic pathways for cancer progression that can be targeted for the prediction, treatment, and prevention of cancer.