Preliminary study on the assessment of early cartilage degeneration by quantitative ultrashort echo time magnetic resonance imaging in vivo
Preliminary study on the assessment of early cartilage degeneration by quantitative ultrashort echo time magnetic resonance imaging in vivo
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DOI：
10.21037/qims-21-1181
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发表时间：
2022-04-14
影响因子：
2.8
通讯作者：
Tang, Guangyu
中科院分区：
文献类型：
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作者：
Su, Xiaolian;Zhang, Yixuan;Tang, Guangyu
背景：探讨定量超短回波时间磁共振成像(UTE-MRI)技术评价活体早期软骨退变的可行性。方法：以膝关节骨关节炎(OA)为主诉的膝关节疼痛患者46例。我们使用不同的定量UTE-MRI技术进行MRI检查，包括基于UTE的磁化转移(MT)、UTE绝热Tlp和UTE-T2*标测在3.0T临床磁共振(MR)扫描仪(MR750；GE Healthcare，密尔沃基，威斯康星州，美国)上进行。分别在股骨内侧和外侧以及相应的胫骨内侧和外侧平台上手工绘制三个感兴趣区(ROI)。最终纳入561个ROI(每个膝关节12个ROI)，根据MRI骨关节炎膝关节评分(MOAKS)分为3组：正常(MOAKS 0，n=175)、轻度退变(MOAKS 1，n=283)、中度退变(MOAKS 2，n=103)。采用单因素方差分析(ANOVA)和Tamhane‘s T2检验比较不同组间UTE定量标志物的差异。采用Spearman相关分析评估UTE生物标志物与Moaks分级的相关性。结果：UTE-MT比值和UTE-绝热T1 Rho值与Moaks分级呈中度相关(r=-0.523，P
Background: To investigate the feasibility of quantitative ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques for assessing early cartilage degeneration in vivo.Methods: A total of 46 patients with knee pain due to osteoarthritis (OA) as the main complaint were recruited into the study. We performed MRI examinations with different quantitative UTE-MRI techniques, including UTE-based magnetization transfer (MT), UTE-adiabaticTlp, and UTE-T2* mapping on a 3.0T clinical magnetic resonance (MR) scanner (MR750; GE Healthcare, Milwaukee, WI, USA). Three regions of interest (ROIs) were manually drawn on the medial and lateral femoral condyles and the corresponding medial and lateral tibial plateaus, respectively. A total of 561 ROIs (12 ROIs for each knee) were finally included and divided into 3 groups according to the MRI Osteoarthritis Knee Score (MOAKS): normal (MOAKS 0, n=175), mild degeneration (MOAKS 1, n=283), and moderate degeneration (MOAKS 2, n=103). One-way analysis of variance (ANOVA) and Tamhane's T2 test were used to compare the differences of quantitative UTE;-biomarkers among different groups. The analysis of Spearman's correlation was used to assess the correlation between the UTE-biomarkers and MOAKS grading. The diagnostic efficacy of different quantitative UTE-MRI techniques for detecting mild cartilage degeneration was evaluated using the receiver operating characteristic (ROC) curve.Results: The UTE-MT ratio (UTE-MTR) and the UTE-adiabatic T1 rho values had a moderate correlation with the MOAKS grading (r=-0.523, P