Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease.
Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease.
复制标题
凋亡：心血管疾病的一种新调节机制。
DOI：
10.2147/jir.s308177
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发表时间：
2021
影响因子：
4.5
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Ji N;Qi Z;Wang Y;Yang X;Yan Z;Li M;Ge Q;Zhang J
焦亡是一种促炎性细胞死亡。与细胞自噬和细胞凋亡相比，细胞凋亡在形态学和机制上有其独特的特点。具体地说，焦亡是一种由Gasdermin家族介导的细胞溶解，释放炎性细胞因子IL-1β和IL-18。其作用机制有三种不同的形式，即caspase-1介导的、caspase-4/5/11介导的和caspase-3介导的。大量的研究证明，焦亡与心血管疾病密切相关。本文综述了近年来肝纤维化与心肌梗死、缺血再灌注、动脉粥样硬化、糖尿病性心肌病、心律失常、心力衰竭、高血压及川崎的相关研究进展。因此，我们认为焦亡可能是心血管领域的一个新的治疗靶点。
Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field.