45S5 Bioglass®-derived glass-ceramic scaffolds for bone tissue engineering
45S5 Bioglass®-derived glass-ceramic scaffolds for bone tissue engineering
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DOI：
10.1016/j.biomaterials.2005.11.025
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发表时间：
2006-04-01
期刊：
影响因子：
14
通讯作者：
Boccaccini, AR
中科院分区：
文献类型：
--
作者：
Chen, QZZ;Thompson, ID;Boccaccini, AR
使用45 S5 Bioglass（R）粉末通过复制技术首次制造了三维（3D）、高度多孔、机械活性、生物活性和可生物降解的支架。在最佳烧结条件（1000 ℃/1 h）下，发生了泡沫支柱的几乎完全致密化，并形成了Na 2Ca 2Si 3 O 9的细晶体，这赋予了支架对于该泡沫结构的最高可能的压缩和弯曲强度。重要的发现是，机械强度强的结晶相Na 2Ca 2Si 3 O 9在模拟体液中浸泡28天后可以转变为无定形磷酸钙相，并且可以通过控制烧结45 S5生物玻璃的结晶度来定制转变动力学（R）。因此，理想支架的目标是在保持生物活性的同时暂时提供良好的机械支撑，并且可以在后期阶段以可定制的速率生物降解，这一目标可以通过开发的基于Bioglass（R）的支架来实现。(c)2005爱思唯尔有限公司保留所有权利。
Three-dimensional (3D), highly porous, mechanically competent, bioactive and biodegradable scaffolds have been fabricated for the first time by the replication technique using 45S5 Bioglass (R) powder. Under an optimum sintering condition (1000 degrees C/1 h), nearly full densification of the foam struts occurred and fine crystals of Na2Ca2Si3O9 formed, which conferred the scaffolds the highest possible compressive and flexural strength for this foam structure. Important findings are that the mechanically strong crystalline phase Na2Ca2Si3O9 can transform into an amorphous calcium phosphate phase after immersion in simulated body fluid for 28 days, and that the transformation kinetics can be tailored through controlling the crystallinity of the sintered 45S5 Bioglass (R). Therefore, the goal of an ideal scaffold that provides good mechanical support temporarily while maintaining bioactivity, and that can biodegrade at later stages at a tailorable rate is achievable with the developed Bioglass (R)-based scaffolds. (c) 2005 Elsevier Ltd. All rights reserved.