Micro and nanoparticle deposition in human nasal passage pre and post virtual maxillary sinus endoscopic surgery
Micro and nanoparticle deposition in human nasal passage pre and post virtual maxillary sinus endoscopic surgery
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DOI：
10.1016/j.resp.2012.03.002
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发表时间：
2012-05-31
影响因子：
2.3
通讯作者：
Bagheri, Mohammad Hadi
中科院分区：
文献类型：
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作者：
Abouali, Omid;Keshavarzian, Erfan;Bagheri, Mohammad Hadi
在虚拟钩突切除术和中鼻窦造口术之前和之后开发了真实的人类鼻道 3D 模型。 3D 计算域由健康受试者的一系列冠状 CT 扫描图像构建。然后通过切除钩突并暴露上颌窦窦部，对左侧鼻道进行虚拟钩突切除术和上颌窦造口术。对于与低或中度活动相对应的几种呼吸频率，在虚拟常规上颌窦内窥镜手术前后对鼻道中的气流进行了数值模拟。分析并比较术前术后病例鼻腔气道、上颌窦和额窦的气流分布。使用拉格朗日轨迹分析方法来评估微粒在鼻道和上颌窦中的路径和沉积。扩散模型用于纳米粒子传输和沉积分析。评估并比较术前和术后条件下鼻窦中吸入的微米颗粒和纳米颗粒的沉积率。结果显示，上颌窦内窥镜手术后，由于气流渗透进入窦腔，吸入的纳米和微粒很容易进入上颌窦。这与术前的情况形成鲜明对比，术前几乎没有颗粒进入鼻窦。这些结果对于更好地了解鼻窦内窥镜手术对患者暴露于颗粒污染和吸入药物输送的影响具有重要意义。鼻窦内明显较高的气流速度和颗粒沉积可能是一些患者在上颌窦内窥镜手术后报告的不适的原因。 (C) 2012 Elsevier B.V. 保留所有权利。
Realistic 3-D models of the human nasal passages were developed pre and post virtual uncinectomy and Middle Meatal Antrostomy. A 3-D computational domain was constructed by a series of coronal CT scan images from a healthy subject. Then a virtual uncinectomy intervention and maxillary antrostomy were performed on the left nasal passage by removing the uncinate process and exposing the maxillary sinus antrum. For several breathing rates corresponding to low or moderate activities, the airflows in the nasal passages were simulated numerically pre and post virtual routine maxillary sinus endoscopic surgery. The airflow distribution in the nasal airway, maxillary and frontal sinuses were analyzed and compared between pre and post surgery cases. A Lagrangian trajectory analysis approach was used for evaluating the path and deposition of microparticles in the nasal passages and maxillary sinuses. A diffusion model was used for nanoparticle transport and deposition analysis. The deposition rate of the inhaled micro and nanoparticles in the sinuses were evaluated and compared for pre and post operation conditions. The results showed that after maxillary sinus endoscopic surgery, the inhaled nano and microparticles can easily enter this sinus due to penetration of the airflow into the sinus cavity. This was in contrast to the preoperative condition in which almost no particles entered the sinuses. These results could be of importance for a better understanding of the effect of sinus endoscopic surgery on patient exposure to particulate pollution and inhalation drug delivery. The significantly higher airflow rate and particle deposition in the sinus could be a reason for the discomfort reported by some patient after maxillary sinus endoscopic surgery. (C) 2012 Elsevier B.V. All rights reserved.