Recurrent childhood anaplastic large cell lymphoma: a retrospective analysis of registered cases in Japan
Recurrent childhood anaplastic large cell lymphoma: a retrospective analysis of registered cases in Japan
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DOI：
10.1111/j.1365-2141.2005.05910.x
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发表时间：
2006-03-01
影响因子：
6.5
通讯作者：
Tsurusawa, M
中科院分区：
文献类型：
--
作者：
Mori, T;Takimoto, T;Tsurusawa, M
本文报告了26例日本儿童复发性间变性大细胞淋巴瘤的回顾性研究。第一次复发的中位数为10。最初诊断后5个月。24名患者获得了第二次缓解。中位随访期为47个月后，18例患者仍然存活：15例患者处于第二次完全缓解（CR）， 3例患者处于第三次完全缓解或更晚。5年总生存率和无复发生存率分别为61 +/- 12%和51 +/- 12%。在第二次CR期间接受同种异体造血干细胞移植的患者表现出优于其他患者的结果。
This report presents a retrospective study of 26 Japanese children with recurrent anaplastic large cell lymphoma. The first relapses were documented at a median of 10(.)5 months after the initial diagnosis. Twenty-four patients achieved a second remission. After a median follow-up period of 47 months, 18 patients are still alive: 15 patients are in second complete remission (CR), three patients are in third CR or later. The 5 year overall and relapse-free survival rates were 61 +/- 12% and 51 +/- 12% respectively. The patients who received allogeneic haematopoietic stem cell transplantation during second CR showed a superior outcome to other patients.