Poly(ethylene glycol)-Containing Hydrogel Surfaces for Antifouling Applications in Marine and Freshwater Environments
Poly(ethylene glycol)-Containing Hydrogel Surfaces for Antifouling Applications in Marine and Freshwater Environments
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DOI：
10.1021/bm800547m
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发表时间：
2008-10-01
影响因子：
6.2
通讯作者：
Liedberg, Bo
中科院分区：
文献类型：
--
作者：
Ekblad, Tobias;Bergstroem, Gunnar;Liedberg, Bo
这项工作描述了薄的蛋白质耐聚乙二醇（PEG）为基础的水凝胶涂层的制造，表征和生物学评价的抗肿瘤应用。该涂层是通过自由基聚合硅烷化的玻璃和硅和聚苯乙烯覆盖的硅和金。通过红外光谱、椭圆偏振仪和接触角测量等手段对涂层的物理化学性能进行了表征。特别地，在六个月的时间内评估涂层在人造海水中的化学稳定性。这些测量结果表明，在所选择的测试条件下，降解过程缓慢，涂层厚度和组成在此期间仅发生轻微变化。一个广泛的和不同的组的海洋和淡水污损生物的沉降行为进行了评估。测试的生物是藤壶幼虫（藤壶），藻类游动孢子（石莼linza），硅藻（舟形藻perminuta），和三种细菌物种（Cobetia marina，Marinocarbonoclasticus，和荧光假单胞菌）。生物学结果表明，该水凝胶涂层在沉降和去除方面表现出优异的生物相容性。
This work describes the fabrication, characterization, and biological evaluation of a thin protein-resistant poly(ethylene glycol) (PEG)-based hydrogel coating for antifouling applications. The coating was fabricated by free-radical polymerization on silanized glass and silicon and on polystyrene-covered silicon and gold. The physicochemical properties of the coating were characterized by infrared spectroscopy, ellipsometry, and contact angle measurements. In particular, the chemical stability of the coating in artificial seawater was evaluated over a six-month period. These measurements indicated that the degradation process was slow under the test conditions chosen, with the coating thickness and composition changing only marginally over the period. The settlement behavior of a broad and diverse group of marine and freshwater fouling organisms was evaluated. The tested organisms were barnacle larvae (Balanus amphitrite), algal zoospores (Ulva linza), diatoms (Navicula perminuta), and three bacteria species (Cobetia marina, Marinobacter hydrocarbonoclasticus, and Pseudomonas fluorescens). The biological results showed that the hydrogel coating exhibited excellent antifouling properties with respect to settlement and removal.