CHANGES IN ANTIBODY-TITERS IN CATTLE INFECTED CLINICALLY AND SUBCLINICALLY WITH BOVINE LEUKEMIA-VIRUS
CHANGES IN ANTIBODY-TITERS IN CATTLE INFECTED CLINICALLY AND SUBCLINICALLY WITH BOVINE LEUKEMIA-VIRUS
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DOI：
10.1002/ijc.2910300517
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发表时间：
1982-01-01
影响因子：
6.4
通讯作者：
SAKAMOTO, Y
中科院分区：
文献类型：
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作者：
KONO, Y;SENTSUI, H;SAKAMOTO, Y
用免疫扩散法研究了牛白血病病毒(BLV)蛋白和糖蛋白抗体在两组黄牛体内的变化。在3年内发生流行性牛白血病的1组牛(10头)中，有7头牛的抗体滴度在持续数月至数年的一段时间后逐渐升高。最终效价比最初的效价高出8-32倍。其余3例滴度变化不大。在10只患有肿瘤的动物中，有3只在极端情况下出现滴度下降。第2组牛(110头)亚临床感染BLV，1~3年滴度变化范围为最低滴度的4倍至无变化。在对一种BLV抗原抗体水平较低的牛中，少数牛对相应的抗原呈阴性反应。
Changes in titers of antibodies to protein and glycoprotein antigens of bovine leukemia virus (BLV) were investigated by immunodiffusion in 2 groups of cattle. In 1 group of cattle (10 head) which developed enzootic bovine leukosis during the observation period of 3 yr, 7 showed a gradual increase in antibody titers following a period of level antibody titers that persisted for several months to several years. The titer was finally 8-32 times higher than the initial titer. The remaining 3 showed little change in titer. Of the 10 animals with tumors, 3 showed a decrease in the titer when they were in extremis. In the 2nd group of cattle (110 head) which were infected with BLV subclinically, the change in the titers during 1 and 3 yr ranged from no change to 4 times the lowest titer observed. Of the cattle which had a low level of antibody to 1 of the BLV antigens, a few became negative reactors to the respective antigen.