The apicoplast: now you see it, now you don't.
The apicoplast: now you see it, now you don't.
复制标题
DOI：
10.1016/j.ijpara.2016.08.005
复制
发表时间：
2017-02
影响因子：
4
通讯作者：
Yeh E
中科院分区：
文献类型：
--
作者：
McFadden GI;Yeh E
寄生虫，如疟原虫和弓形虫，具有一种与藻类和植物的叶绿体同源的退化体。叶绿体(称为顶生质体；顶复合体)是非光合作用的，数量大大减少，但具有明显的内共生祖先，包括编码RNA和蛋白质的环状基因组和一套细菌生物合成途径。本文回顾了质外体的最初发现，并叙述了关于质外体起源、生物发生和功能的主要新见解。我们通过研究如何在体外从疟疾寄生虫中移除顶生质体，最终通过化学补充完成其减少，从而得出结论。
Parasites such as Plasmodium and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of algae and plants. The plastid (known as the apicoplast; for apicomplexan plastid) is non-photosynthetic and very much reduced, but has clear endosymbiotic ancestry including a circular genome that encodes RNAs and proteins and a suite of bacterial biosynthetic pathways. Here we review the initial discovery of the apicoplast, and recount the major new insights into apicoplast origin, biogenesis and function. We conclude by examining how the apicoplast can be removed from malaria parasites in vitro, ultimately completing its reduction by chemical supplementation.