P50 sensory gating in panic disorder
P50 sensory gating in panic disorder
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DOI：
10.1016/j.jpsychires.2006.02.006
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发表时间：
2006-09-01
影响因子：
4.8
通讯作者：
Lara, Diogo R.
中科院分区：
文献类型：
--
作者：
Ghisolfi, Eduardo S.;Heldt, Elizeth;Lara, Diogo R.
以往的研究表明，惊恐障碍（PD）患者的感觉信息处理的早期阶段是异常的前脉冲抑制。为了进一步研究惊恐障碍的感觉门控功能，我们进行了一项病例对照研究，样本28例PD患者，28名正常人和28名精神分裂症患者，评估听觉中潜伏期诱发电位P50的双击范例作为测量的感觉门控。与正常受试者相比，PD受试者表现出较弱的感觉门控，如通过较高的P50比率（62.5%对45.4%，p = 0.03）和较高的S2（测试）振幅（3.5 μ V对2.1 μ V，p = 0.01）所证明的。与健康对照者相比，精神分裂症受试者显示出比正常受试者更高的P50比率（79.2%与45.4%，p < 0.01）和更高的S2振幅（3.3 μ V与2.1 μ V，p = 0.01），但与PD受试者没有统计学差异（p > 0.1）。本研究证实了最近的发现，感觉门控功能障碍的PD。进一步的研究仍然是必要的，以更好地了解这种神经生理功能障碍的病理生理学及其性质作为一种特征或状态标记。(c)2006爱思唯尔有限公司保留所有权利。
Previous studies with prepulse inhibition in panic disorder (PD) have suggested that the early stages of sensory information processing are abnormal in patients with PD. To further investigate sensory gating function in panic disorder we performed a case-control study in a, sample of 28 patients with PD, compared to 28 normal subjects and 28 schizophrenic subjects evaluating auditory mid-latency evoked potential P50 in a double-click paradigm as a measure of sensory gating. PD subjects showed weaker sensory gating as evidenced by higher P50 ratios as compared to normal subjects (62.5% vs. 45.4%, p = 0.03) and higher S2 (test) amplitude (3.5 mu V vs. 2.1 mu V, p = 0.01). Schizophrenic subjects when compared to healthy controls showed higher P50 ratios as compared to normal subjects (79.2% vs. 45.4%, p < 0.01) and higher S2 amplitude (3.3 mu V vs. 2.1 mu V, p = 0.01), but were not statistically different from PD subjects (p > 0.1). The present study corroborates recent findings of sensory gating dysfunction in PD. Further studies are still necessary to better understand the pathophysiology of this neurophysiological dysfunction and its nature as a trait or a state marker. (c) 2006 Elsevier Ltd. All rights reserved.