Advances in biologic augmentation for rotator cuff repair.
Advances in biologic augmentation for rotator cuff repair.
复制标题
肩袖修复生物增强的进步。
DOI：
10.1111/nyas.13267
复制
发表时间：
2016-11
影响因子：
5.2
通讯作者：
Levine WN
中科院分区：
文献类型：
--
作者：
Patel S;Gualtieri AP;Lu HH;Levine WN
肩袖撕裂是一种非常常见的肩关节损伤，通常需要外科手术进行修复。尽管肩袖修复术的手术技术取得了进步，但由于许多因素导致的愈合能力差，术后失败的发生率很高。肌腱-骨整合的复杂性固有地提出了修复的挑战，因为肌腱和骨之间的大的生物力学不匹配和天然组织的再生不足，导致纤维血管瘢痕组织的形成。因此，已经研究了各种生物增强方法来改善肩袖修复愈合。这篇综述强调了三种基本方法的最新进展，生物增强功能和一体化的肌腱-骨修复。首先，探索，应用和交付的生长因子，以提高天然组织的再生进行了讨论。第二，应用干细胞和其他细胞为基础的治疗，以补充受损组织更好地愈合覆盖。最后，这篇综述将强调相容性生物材料的开发和应用，以更好地概括肌腱-骨界面，并改善生物因子的输送，以增强综合修复。
Rotator cuff tear is a very common shoulder injury that often necessitates surgical intervention for repair. Despite advances in surgical techniques for rotator cuff repair, there is a high incidence of failure after surgery because of poor healing capacity attributed to many factors. The complexity of tendon-to-bone integration inherently presents a challenge for repair because of a large biomechanical mismatch between the tendon and bone and insufficient regeneration of native tissue, leading to the formation of fibrovascular scar tissue. Therefore, various biological augmentation approaches have been investigated to improve rotator cuff repair healing. This review highlights recent advances in three fundamental approaches for biological augmentation for functional and integrative tendon–bone repair. First, the exploration, application, and delivery of growth factors to improve regeneration of native tissue is discussed. Second, applications of stem cell and other cell-based therapies to replenish damaged tissue for better healing is covered. Finally, this review will highlight the development and applications of compatible biomaterials to both better recapitulate the tendon–bone interface and improve delivery of biological factors for enhanced integrative repair.