Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer
Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer
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DOI：
10.3748/wjg.v22.i11.3117
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发表时间：
2016-03-21
影响因子：
4.3
通讯作者：
Al-Hassi, Hafid Omar
中科院分区：
文献类型：
--
作者：
Landy, Jonathan;Ronde, Emma;Al-Hassi, Hafid Omar
炎症性肠病的特征在于损害上皮屏障完整性的炎症。肠上皮不仅是一个静态屏障，而且已经进化出复杂的机制来控制和调节细菌与粘膜表面的相互作用。顶端紧密连接蛋白在维持上皮屏障功能和控制细胞旁通透性方面至关重要。紧密连接蛋白作为炎症性肠病中上皮屏障功能的关键参与者的改变的特征正在迅速增强我们对疾病发病机制的关键机制以及新的治疗机会的理解。在这里，我们给出了一个概述，最近的文献集中在紧密连接蛋白的作用，特别是claudins，在炎症性肠病和炎症性肠病相关的结直肠癌。
Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.