Th1, Th2, and Th17 cells are dysregulated, but only Th17 cells relate to C‐reactive protein, D‐dimer, and mortality risk in Stanford type A aortic dissection patients
Th1, Th2, and Th17 cells are dysregulated, but only Th17 cells relate to C‐reactive protein, D‐dimer, and mortality risk in Stanford type A aortic dissection patients
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Th1、Th2 和 Th17 细胞失调，但只有 Th17 细胞与斯坦福 A 型主动脉夹层患者的 C-反应蛋白、D-二聚体和死亡风险相关
DOI：
10.1002/jcla.24469
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Hongguang Han
中科院分区：
文献类型：
--
作者：
Mowei Song;Li Deng;Hongtao Shen;Guofu Zhang;Hang Shi;Erjun Zhu;Qingping Xia;Hongguang Han
辅助性T（Th）细胞与血管炎症、内皮功能障碍和动脉粥样硬化形成密切相关，这些是主动脉夹层（AD）的标志。为探讨Th 1、Th 2和Th 17细胞在斯坦福大学A型AD患者中的临床应用价值，选取斯坦福大学A型AD患者80例，非AD胸痛患者40例。采用流式细胞仪检测所有受试者外周血CD 4 + T细胞中Th 1、Th 2和Th 17细胞。记录斯坦福大学A型AD患者的30 d死亡率，与非AD患者相比，斯坦福大学A型AD患者的Th 1和Th 17细胞较高，而Th 2细胞较低（均p <0. 001）。同时，Th 1细胞（曲线下面积（AUC）：0.734，95%置信区间（CI）：0.640-0.828）、Th 2细胞（AUC：0.841，95% CI：0.756-0.925）和Th 17细胞（AUC：0.898，95% CI：0.839-0.957）可以区分斯坦福大学A型患者和非AD患者。此外，在斯坦福大学A型AD患者中，Th 1细胞（p = 0.037）和Th 17细胞（p = 0.001）与CRP正相关，Th 17细胞（p = 0.039）也与D-二聚体正相关。此外，与存活者相比，死亡者的Th 17细胞升高（p = 0.001），也可以估计斯坦福大学A型AD患者的30天死亡风险，AUC为0.741（95%CI：0.614-0.867），与CRP值相似（AUC：0.771，95%CI：0.660-0.882），但低于D-二聚体值（AUC：0.818，95%CI：0.722-0.913）.在斯坦福大学A型AD患者中，Th 1、Th 2和Th 17细胞失调，但只有Th 17细胞与CRP、D-二聚体和30天死亡风险相关。
T helper (Th) cells are closely involved in vascular inflammation, endothelial dysfunction, and atherogenesis, which are the hallmarks of aortic dissection (AD). This study aimed to evaluate the clinical value of Th1, Th2, and Th17 cell measurements in Stanford type A AD patients.Stanford type A AD patients (N=80) and non-AD patients with chest pain (N = 40) were recruited. Then, Th1, Th2, and Th17 cells in peripheral blood CD4+ T cells from all participants were detected by flow cytometry. The 30-day mortality of Stanford type A AD patients was recorded.Th1 and Th17 cells were higher, while Th2 cells were lower in Stanford type A AD patients compared with non-AD patients (all p < 0.001). Meanwhile, Th1 cells (area under curve (AUC): 0.734, 95% confidence interval (CI): 0.640-0.828), Th2 cells (AUC: 0.841, 95% CI: 0.756-0.925), and Th17 cells (AUC: 0.898, 95% CI: 0.839-0.957) could distinguish Stanford type A patients from non-AD patients. Moreover, Th1 cells (p = 0.037) and Th17 cells (p = 0.001) were positively related to CRP, and Th17 cells (p = 0.039) were also positively associated with D-dimer in Stanford type A AD patients. Furthermore, Th17 cells were elevated in deaths compared with survivors (p = 0.001), also, it could estimate 30-day mortality risk in Stanford type A AD patients with an AUC of 0.741 (95% CI: 0.614-0.867), which was similar to the value of CRP (AUC: 0.771, 95% CI: 0.660-0.882), but lower than the value of D-dimer (AUC: 0.818, 95% CI: 0.722-0.913).Th1, Th2, and Th17 cells are dysregulated, but only the Th17 cells relate to CRP, D-dimer, and 30-day mortality risk in Stanford type A AD patients.
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DOI：
10.5114/aoms.2017.67280
发表时间：
2017-04-01
期刊：
Archives of medical science : AMS
影响因子：
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作者：
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