Peptide ligand-mediated trade-off between plant growth and stress response
Peptide ligand-mediated trade-off between plant growth and stress response
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DOI：
10.1126/science.abq5735
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发表时间：
2022-10-14
期刊：
影响因子：
56.9
通讯作者：
Matsubayashi, Yoshikatsu
中科院分区：
文献类型：
--
作者：
Ogawa-Ohnishi, Mari;Yamashita, Tomohide;Matsubayashi, Yoshikatsu
决定是生长还是将能量转移到应激反应中是植物在波动环境中生存的主要生理权衡。我们表明，三个富含亮氨酸的重复受体激酶（LRR-RKs）作为直接的配体感知受体的植物肽含有硫酸酪氨酸（PSY）家族肽和介导两个相反的途径之间的切换。与已知的在配体结合时激活信号传导的LRR-RKs相反，PSY受体（PSYR）在配体耗尽时激活编码应激反应转录因子的各种基因的表达。PSYRs的缺失导致植物对生物和非生物胁迫的耐受性缺陷。这种配体剥夺依赖性激活系统可能使植物能够在靠近代谢功能障碍的受损部位的组织中对应激反应进行调谐调节，其中配体产生受损。
Deciding whether to grow or to divert energy to stress responses is a major physiological trade-off for plants surviving in fluctuating environments. We show that three leucine-rich repeat receptor kinases (LRR-RKs) act as direct ligand-perceiving receptors for PLANT PEPTIDE CONTAINING SULFATED TYROSINE (PSY)-family peptides and mediate switching between two opposing pathways. By contrast to known LRR-RKs, which activate signaling upon ligand binding, PSY receptors (PSYRs) activate the expression of various genes encoding stress response transcription factors upon depletion of the ligands. Loss of PSYRs results in defects in plant tolerance to both biotic and abiotic stresses. This ligand-deprivation-dependent activation system potentially enables plants to exert tuned regulation of stress responses in the tissues proximal to metabolically dysfunctional damaged sites where ligand production is impaired.