A sparse covarying unit that describes healthy and impaired human gut microbiota development
A sparse covarying unit that describes healthy and impaired human gut microbiota development
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DOI：
10.1126/science.aau4735
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发表时间：
2019-07-12
期刊：
影响因子：
56.9
通讯作者：
Gordon, Jeffrey I.
中科院分区：
文献类型：
--
作者：
Raman, Arjun S.;Gehrig, Jeanette L.;Gordon, Jeffrey I.
鉴于其组成部分之间可能的相互作用数量，表征人类肠道微生物群的组织是一项艰巨的挑战。使用最初应用于金融市场的统计方法，我们测量了从1到60个月大的孟加拉国出生队列健康成员的微生物群中细菌类群之间的时间保守协方差。结果揭示了由15种共变细菌分类群组成的“生态群”，这些分类群提供了来自这个国家和其他低收入国家的健康儿童微生物群发育的简明描述，并提供了监测接受治疗性食物治疗的营养不良儿童社区修复的方法。生态群的人口动态的特点概括在gnotobiotic仔猪，因为他们从完全断奶的状态，消费一个有代表性的孟加拉国饮食的独家牛奶喂养过渡。
Characterizing the organization of the human gut microbiota is a formidable challenge given the number of possible interactions between its components. Using a statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in the microbiota of healthy members of a Bangladeshi birth cohort sampled from I to 60 months of age. The results revealed an "ecogroup" of 15 covarying bacterial taxa that provide a concise description of microbiota development in healthy children from this and other low-income countries, and a means for monitoring community repair in undernourished children treated with therapeutic foods. Features of ecogroup population dynamics were recapitulated in gnotobiotic piglets as they transitioned from exclusive milk feeding to a fully weaned state consuming a representative Bangladeshi diet.