Effects of Loops and Nucleotides in G-Quadruplexes on Their Interaction with an Azacalixarene, Methylazacalix[6]pyridine
Effects of Loops and Nucleotides in G-Quadruplexes on Their Interaction with an Azacalixarene, Methylazacalix[6]pyridine
复制标题
G-四链体中的环和核苷酸对其与 Azacalixarene、甲基azacalix[6]吡啶相互作用的影响
DOI：
10.1021/jp204154m
复制
发表时间：
2011-11-03
影响因子：
3.3
通讯作者：
Wang, Mei-Xiang
中科院分区：
文献类型：
--
作者：
Guan, Ai-Jiao;Zhang, En-Xuan;Wang, Mei-Xiang
G-四链体配体设计的一个新趋势是构建一种结合剂，其不仅能够区分G-四链体和DNA，而且能够区分各种G-四链体结构。甲基氮杂杯[6]吡啶（MACP 6）是一种新型的氮杂杯芳烃，具有柔性构象，与大多数G-四链体相互作用时，均表现出诱导圆二色性信号。诱导信号的强度强烈依赖于G-四链体的拓扑结构。进一步的证据表明，这些信号可以归因于MACP 6与G-四链体的环的优选结合，这依赖于环中核苷酸的性质。
A novel trend in G-quadruplexligand design is to build a binder that is able to not only discriminate G-quadruplex from duplex-DNA, but also among various G-quadruplex structures. Methylazacalix[6]pyridine (MACP6), a new type of azacalixarene with flexible conformation, exhibits induced circular dichroism signals when interacted with most of G-quadruplexes. The intensities of the induced signals are strongly dependent on the topology of G-quadruplexes. Further evidence has shown that these signals can be ascribed to the preferred binding of MACP6 to the loops of G-quadruplexes, which rely on the nature of nucleotides in the loops.