Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization.
Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization.
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DOI：
10.5101/nbe.v4i1.p35-40
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发表时间：
2012
影响因子：
--
通讯作者：
Aslan K
中科院分区：
文献类型：
--
作者：
Mohammed M;Syed MF;Bhatt MJ;Hoffman EJ;Aslan K
在本文中，我们展示了应用金属辅助和微波加速蒸发结晶（MA-MAEC）技术快速和选择性结晶的小药物化合物。即对乙酰氨基酚。随后通过光学显微镜、粉末X射线衍射（PXRD）和拉曼光谱对晶体进行表征，表明在各种实验条件下不同晶形的定量选择性生长。对乙酰氨基酚晶体主要以I型（99%）在室温下在空白载玻片上生长。使用微波能量在SIF上生长纯度为39%的II型晶体。
In this paper, we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique to rapid and selective crystallization of a small drug compound. i.e. acetaminophen. Subsequent characterization of the crystals by optical microscopy, powder X-ray diffraction (PXRD) and Raman spectroscopy showed quantitatively selective growth of different crystal forms at various experimental conditions. Acetaminophen crystals were grown predominantly as Form I (99%) on blank glass slides at room temperature. Form II crystals with 39% purity grown on SIFs using microwave energy.