Assessment of Various Types of US Findings after Irreversible Electroporation in Porcine Liver: Comparison with Radiofrequency Ablation
Assessment of Various Types of US Findings after Irreversible Electroporation in Porcine Liver: Comparison with Radiofrequency Ablation
复制标题
DOI：
10.1016/j.jvir.2014.11.007
复制
发表时间：
2015-02-01
影响因子：
2.9
通讯作者：
Oshiro, Hisashi
中科院分区：
文献类型：
--
作者：
Sugimoto, Katsutoshi;Moriyasu, Fuminori;Oshiro, Hisashi
目的：评估各种超声（US）检查结果，包括B型、剪切波弹性成像（SWE）和增强超声，在基于放射病理学相关性的不可逆电穿孔（IRE）后准确评估消融Inargins，并比较IRE和射频（RF）消融之间的这些结果。材料和方法：在三只猪肝中进行了体内IRE（n = 9）和RF消融（n = 3）。在手术后立即和90分钟后，通过每种方法对每个消融区进行成像。根据末次消融后2小时处死的动物样本的大体病理学和组织病理学结果评价消融区。结果：IRE后90 min B超显示消融区为高回声区，周围有高回声边缘，两者具有良好的相关性（12 = 0.905，P < .0001）与大体病理结果：SWE显示IRE消融区的组织硬度随时间增加。对比增强超声显示IRE消融区为门脉期的少血管区，与大体病理结果相关性最高（r2 = 0.923，P <0.0001）。B型超声可清晰显示射频消融区域。SWE显示，射频消融后的组织硬度高于IRE后。对比增强的US描绘的RF消融区avascularizations.Conclusions：IRE和RF消融区可以最准确地预测门静脉期对比增强的US测量消融后立即获得。
Purpose: To assess various ultrasound (US) findings, including B-mode, shear-wave elastography (SWE), and contrastenhanced US, in accurately assessing ablation Inargins after irreversible electroporation (IRE) based on radiologic pathologic correlation, and to compare these findings between IRE and radiofrequency (RF) ablation.Materials and Methods: IRE (n = 9) and RF ablation (n = 3) were performed in-vivo in three pig livers. Each ablation zone was imaged by each method immediately after the procedure and 90 minutes later. Ablation zones were evaluated based on gross pathologic and histopathologic findings in samples from animals euthanized 2 hours after the last ablation. The characteristics and dimensions of the histologic ablation zones were qualitatively and quantitatively compared against each US finding.Results: In B-mode US at 90 minutes after IRE, the ablation zones appeared as hyperechoic areas with a peripheral hyperechoic rim, showing excellent correlation (12 = 0.905, P < .0001) with gross pathologic findings: SWE showed that tissue stiffness in the IRE ablation zones increased over time. Contrast-enhanced US depicted the IRE ablation zones as hypovascular areas in the portal phase, and showed the highest correlation (r2 = 0.923, P < .0001) with gross pathologic findings. The RF ablation zones were clearly visualized by B-mode US. SWE showed that tissue stiffness after RF ablation was higher than after IRE. Contrast-enhanced US depicted the RF ablation zones as avascular areas.Conclusions: IRE and RF ablation zones can be most accurately predicted by portal-phase contrast-enhanced US measurements obtained imMediately after ablation.