Recovery of drug-resistant influenza virus from immunocompromised patients: A case series
Recovery of drug-resistant influenza virus from immunocompromised patients: A case series
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DOI：
10.1086/500465
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发表时间：
2006-03-15
影响因子：
6.4
通讯作者：
Hayden, FG
中科院分区：
文献类型：
--
作者：
Ison, MG;Gubareva, LV;Hayden, FG
对抗病毒药物具有耐药性的流感病毒在免疫功能低下的患者中出现的频率越来越高，并且可能限制M2和神经氨酸酶（NA）抑制剂的益处。我们记录了3例严重免疫功能低下患者的流感病例，从这些患者中回收了具有抗流感药物耐药分子标志物的病毒变异体。从2例患者中回收的病毒变体在M2、NA（具有先前识别的Glu119Val NA取代）和血凝素基因中存在突变。我们描述了一种新的Asp198 Asn NA突变的流感B病毒和它的敏感性降低奥司他韦和扎那米韦。
Influenza virus with resistance to antiviral drugs emerges with increased frequency in immunocompromised patients and can limit the benefit of M2 and neuraminidase (NA) inhibitors. We document 3 cases of influenza in severely immunocompromised patients from whom virus variants with molecular markers of resistance to anti-influenza drugs were recovered. Virus variants recovered from 2 patients had mutations in the M2, NA (with a previously recognized Glu119Val NA substitution), and hemagglutinin genes. We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir.