Statins for Cardiac and Vascular Protection During and After Cancer Therapy.
Statins for Cardiac and Vascular Protection During and After Cancer Therapy.
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DOI：
10.1007/s11912-022-01212-4
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发表时间：
2022-05
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然癌症治疗提高了总生存率，但癌症治疗的心血管后果使患者面临不良后果的风险增加。本文介绍了迄今为止在接受潜在心脏毒性癌症治疗的个体中，与3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂（或他汀类药物）治疗相关的心血管结局的累积数据。在人类中进行的回顾性观察研究和在动物中进行的随机对照试验表明，他汀类药物可能会降低癌症特异性和全因死亡率。此外，他汀类药物可以减弱癌症治疗引起的左心室射血分数（LVEF）下降和血压升高。观察性研究表明，癌症患者和接受他汀类药物预防心血管事件的主要或次要适应症患者的LVEF下降可能会减弱。大型随机临床试验是必要的，以了解他汀类药物的疗效和潜在的影响，剂量和治疗癌症患者的心血管结局。
Although cancer treatments have increased overall survival rates, the cardiovascular consequences of cancer therapy place patients at an increased risk of adverse outcomes. This manuscript presents data accumulated to date regarding cardiovascular outcomes relating to the administration of 3-hydroxy-3-methylglutarylcoenzyme-A reductase inhibitor (or statin) therapy in individuals receiving potentially cardiotoxic cancer treatments. Retrospective observational studies in humans and randomized controlled trials in animals suggest that statins may reduce cancer-specific and all-cause mortality. Further, statins may attenuate cancer therapy-induced declines in left ventricular ejection fraction (LVEF) and increases in blood pressure. Observational studies suggest a potential attenuation in LVEF decline in patients with cancer and primary or secondary indications to receive a statin for prevention of cardiovascular events. Large randomized clinical trials are warranted to understand the efficacy and potential impacts of statin class, dosage, and duration on cardiovascular outcomes in patients treated for cancer.
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DOI：
10.1016/j.cjca.2014.11.020
发表时间：
2015-03
期刊：
The Canadian journal of cardiology
影响因子：
--
作者：
Chotenimitkhun R;D'Agostino R Jr;Lawrence JA;Hamilton CA;Jordan JH;Vasu S;Lash TL;Yeboah J;Herrington DM;Hundley WG
通讯作者：
Hundley WG
影响因子：
5.2
作者：
Kwon H;Pessin JE
通讯作者：
Pessin JE
亲水性或亲脂性他汀类药物？
影响因子：
3.6
作者：
Climent E;Benaiges D;Pedro-Botet J
通讯作者：
Pedro-Botet J
影响因子：
4.8
作者：
Borahay, Mostafa A.;Kilic, Gokhan S.;Boehning, Darren
通讯作者：
Boehning, Darren
影响因子：
6.2
作者：
Calvillo-Arguelles, Oscar;Abdel-Qadir, Husam;Thavendiranathan, Paaladinesh
通讯作者：
Thavendiranathan, Paaladinesh