The Tohoku Study of Child Development: A cohort study of effects of perinatal exposures to methylmercury and environmentally persistent organic pollutants on neurobehavioral development in Japanese children
The Tohoku Study of Child Development: A cohort study of effects of perinatal exposures to methylmercury and environmentally persistent organic pollutants on neurobehavioral development in Japanese children
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DOI：
10.1620/tjem.202.227
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发表时间：
2004-03-01
影响因子：
2.2
通讯作者：
Satoh, H
中科院分区：
文献类型：
--
作者：
Nakai, K;Suzuki, K;Satoh, H
几项出生队列研究表明，围产期接触甲基汞和环境会产生不利影响。持久性有机污染物。这些化学物质主要是通过食用鱼类摄入的，但日本人对这些化学物质的危害却知之甚少，因为日本人的鱼类消费量很高。目前的研究，东北儿童发育研究，旨在研究围产期接触甲基汞，多氯联苯（PCB），二恶英，农药和其他化学品在日本儿童的影响。687名孕妇参加了这项研究，并签署了书面知情同意书。采集孕妇外周血、脐带血、脐带组织、胎盘和母乳样本进行化学分析。还采集了母亲的头发进行甲基汞分析。对足月出生的婴儿进行神经行为测试：3天龄时的Brazelton新生儿行为评估量表，7个月和18个月龄时的京都心理发展量表和贝利婴儿发展量表，以及7个月龄时的Fagan婴儿智力测试。儿童将持续随访至6-7岁。母亲的食物摄入频率，母亲的智商，社会经济地位和家庭环境作为协变量进行了评估。这项队列研究的结果将使我们能够评估日本儿童神经行为发育与围产期接触甲基汞和环境持久性有机污染物之间的关系。(C)东北大学医学出版社.
Several birth cohort studies have shown adverse effects of perinatal exposures to methylmercury (MeHg) and environmentally. persistent organic pollutants (POPS). These chemicals are ingested mainly through fish consumption, but little is known about the hazardous effects in Japanese, whose fish consumption is high. The present study, the Tohoku Study of Child Development, was designed to examine the effects of perinatal exposures to MeHg, polychlorinated biphenyls (PCB), dioxins, pesticides, and other chemicals in Japanese children. Six hundred eighty-seven pregnant women were participated in this study with their written informed consent. Maternal peripheral blood, cord blood, cord tissue, placenta, and breast milk samples were collected for chemical analysis. Maternal hair was also taken for MeHg analysis. Infants born at full term were assessed by neurobehavioral tests: the Brazelton Neonatal Behavioral Assessment Scale at three days old, the Kyoto Scale of Psychological Development and the Bayley Scales of Infant Development at 7 and 18 months old, and the Fagan Test of Infant Intelligence at 7 months old. The children will be continuously followed up to ages 6-7 years. Maternal food intake frequency, maternal IQ, socioeconomic status, and home environment were assessed as covariates. The results of this cohort study will allow us to evaluate associations between the neurobehavioral development of children and perinatal exposures to MeHg and environmentally POPs in Japan. (C) 2004 Tohoku University Medical Press.