Biochemical Insights into the Role of Guanosine Oxidation on RNA G-Quadruplex
Biochemical Insights into the Role of Guanosine Oxidation on RNA G-Quadruplex
复制标题
鸟苷氧化对 RNA G-四链体作用的生化见解
DOI：
10.31635/ccschem.020.202000173
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发表时间：
2020-01-01
期刊：
影响因子：
11.2
通讯作者：
Zhou, Xiang
中科院分区：
文献类型：
--
作者：
Huang, Hai-Yan;Wang, Shao-Ru;Zhou, Xiang
虽然已经研究了8-oxo-7,8-二氢-2'-二氧鸟苷（狗）在DNA G- Quadruplex上（G4），但8-oxo-7,8-二氢 - 二氢 - 瓜氨酸（ROG）病变的影响对端粒重复rna（Terra）G4 G4 Despeves进行了研究。 Terra的单链和鸟嘌呤特征使其很容易形成ROG病变。我们目前的研究表明，位于Terra的内层和外层的ROG以不同的方式和扰动的RNA复制以及碱基对强度和稳定性影响G4的稳定性。
While 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) on DNA G-quadruplex (G4) has been studied, the influence of 8-oxo-7,8-dihydro-guanosine (rOG) lesions on telomeric repeat-containing RNA (TERRA) G4 deserves an in-depth study. The single-strand and guanine-rich characters of TERRA make it vulnerable to form rOG lesions. Our current study demonstrated that rOG located in the internal layer and external layer of TERRA impacted the G4 stability in different ways and perturbed RNA replication, as well as base-pair strength and stability.