Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case-control study in Chinese women
Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case-control study in Chinese women
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DOI：
10.1186/s12884-020-2802-9
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发表时间：
2020-02-27
影响因子：
3.1
通讯作者：
Mo, Zengnan
中科院分区：
文献类型：
--
作者：
Huang, Shengzhu;Tian, Jiarong;Mo, Zengnan
背景：目前已有大量研究探讨母体血清炎性指标(铁蛋白、C反应蛋白、补体C3、C4)与早产的关系。然而，结果并不一致。因此，这项研究的目的是在嵌套病例对照研究(NCC)中评估母体血清炎症指标与肺结核的关系。方法采用广西出生队列研究方法，对2015年至2016年中国6个城市6个城市6203例5(0/7)~34(6/7)周的孕妇进行新生儿猝死研究。有206例早产妇女(37(0/7)WGA)和412例足月分娩妇女在母亲年龄、出生地点、婴儿性别和采血时WGA相匹配。免疫比浊法测定炎症指标。结果所有炎症指标的最高四分位浓度均高于中位数。调整孕妇年龄后，妊娠早期C反应蛋白水平(C反应蛋白和GT；16.60 mg/L)与早孕期肺结核的危险性相关(OR=2.16，95%CI：1.02~4.56，P=0.044)。C3与早孕期发生肺结核密切相关(OR=2.53，95%CI：1.14~5.64，P=0.023)。此外，C4(p=0.079)和铁蛋白(p=0.067)在肺结核之间没有发现明显的相关性。结论妊娠早期C反应蛋白和补体C3水平升高与肺结核发病风险增加有关。炎性指标可能在肺结核的早期诊断和预后判断中起关键作用。
Background Currently, there are many studies researched the associations between maternal serum inflammatory indicators (i.e. ferritin, C-reactive protein [CRP], C3 and C4) and preterm birth (PTB). The results, however, are inconsistent. Therefore, the aim of this study was to estimate the relationship between maternal serum inflammatory indicators and PTB in a nested case-control (NCC)study. Methods A NCC study was conducted by Guangxi Birth Cohort Study which enrolled a total of 6203 pregnant women between 5(0/7) and 34(6/7) weeks of gestational age (wGA) from six cities in China between 2015 and 2016. There were 206women who delivered preterm (< 37(0/7) wGA), and 412 women who delivered term birth, those women were matched by maternal age, birth place, gender of infants, and wGA at blood collection. The inflammatory indicators were quantified by immunoturbidimetric methods. Results Highest quartile concentrations of all inflammatory indicators were determined versus median. After adjusting for maternal age, high levels of CRP (CRP > 16.60 mg/L) are related to the risk of PTB (OR = 2.16, 95% CI: 1.02-4.56, p = 0.044) in the first trimester. The association of C3 was extremely related to those who delivered PTB (OR = 2.53, 95% CI: 1.14-5.64, p = 0.023) in the first trimester. Moreover, no significant associations were found in C4 (p = 0.079) and ferritin (p = 0.067) between PTB. Conclusions Elevated concentrations of CRP and C3 in the first trimester were associated with increased risk of PTB. Inflammatory indicators may act a pivotal part in early diagnosis and prognosis of PTB.