Potentiation of Gamma Oscillatory Activity through Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex
Potentiation of Gamma Oscillatory Activity through Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex
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DOI：
10.1038/npp.2009.79
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发表时间：
2009-10-01
影响因子：
7.6
通讯作者：
Daskalakis, Zafiris J.
中科院分区：
文献类型：
--
作者：
Barr, Mera S.;Farzan, Faranak;Daskalakis, Zafiris J.
伽马（gamma）频率范围（30-50 Hz）的神经元振荡与认知有关。工作记忆（Working memory，WM）是一种涉及信息在线维护和处理的认知任务，随着认知需求的增加，特别是在背外侧前额叶皮层（dorsolateral prefrontal cortex，DLPFC），gamma振荡也随之增加。伽马振荡的产生和调节归因于使用伽马-氨基丁酸（GABA）作为其主要神经递质的抑制性中间神经元网络。重复经颅磁刺激（rTMS）是一种刺激皮质的非侵入性方法，已被证明可以改变认知和GABA抑制机制，特别是在较高频率（即10-20 Hz）下。我们测量了应用于DLPFC的高频rTMS对健康个体在N-back WM任务期间引起的γ振荡的影响。主动rTMS显著增加了在N-back条件下产生的伽马振荡，具有最大的认知需求。此外，在其他频率范围内没有发现显着变化，表明rTMS选择性地调节额叶脑区的伽马振荡。这些研究结果提供了重要的见解的神经生理机制，高阶认知过程的基础，并建议rTMS可用作认知增强策略，在神经精神疾病，患有认知缺陷。Neuropsychopharmacology（2009）34，2359-2367; doi：10.1038/npp.2009.79;在线发表于2009年7月15日
Neuronal oscillations in the gamma (gamma) frequency range (30-50 Hz) have been associated with cognition. Working memory (WM), a cognitive task involving the on-line maintenance and manipulation of information, elicits increases in gamma oscillations with greater cognitive demand, particularly in the dorsolateral prefrontal cortex (DLPFC). The generation and modulation of gamma oscillations have been attributed to inhibitory interneuron networks that use gamma-aminobutyric acid (GABA) as their principal neurotransmitter. Repetitive transcranial magnetic stimulation (rTMS) represents a non-invasive method to stimulate the cortex that has been shown to modify cognition and GABA inhibitory mechanisms, particularly with higher frequencies (ie, 10-20 Hz). We measured the effect of high-frequency rTMS applied to the DLPFC on gamma-oscillations elicited during the N-back WM task in healthy individuals. Active rTMS significantly increased gamma-oscillations generated during the N-back conditions with the greatest cognitive demand. Further, no significant changes were found in other frequency ranges, suggesting that rTMS selectively modulates gamma-oscillations in the frontal brain regions. These findings provide important insights into the neurophysiological mechanisms that underlie higher-order cognitive processes, and suggest that rTMS may be used as a cognitive enhancing strategy in neuropsychiatric disorders that suffer from cognitive deficits. Neuropsychopharmacology (2009) 34, 2359-2367; doi: 10.1038/npp.2009.79; published online 15 July 2009