Associations among NPPA gene polymorphisms, serum ANP levels, and hypertension in the Chinese Han population
Associations among NPPA gene polymorphisms, serum ANP levels, and hypertension in the Chinese Han population
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中国汉族人群NPPA基因多态性、血清ANP水平与高血压的相关性
DOI：
10.1038/s41371-019-0219-6
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发表时间：
2019-07
影响因子：
2.7
通讯作者：
Yonghong Zhang
中科院分区：
文献类型：
--
作者：
Huan Zhang;Xingbo Mo;Zhengyuan Zhou;Zhengbao Zhu;Xinfeng HuangFu;Tan Xu;Aili Wang;Zhirong Guo;Yonghong Zhang
利钠肽系统在调节血压中起着重要作用。本研究的目的是全面研究NPPA基因snp、血清心房钠素（ANP）水平和高血压之间的关系。在736例新发高血压患者和736例年龄和性别匹配的对照组中，我们测量了血清NT-proANP的浓度和NPPA基因型3标记snp的浓度。高血压患者血清ANP水平明显低于对照组（Wilcoxon双样本检验P = 0.011）。男性亚组（P = 0.0161）和女性亚组（P = 0.0011）差异也有统计学意义。与参照组相比，ANP水平最高四分位数的参与者患高血压的风险显著降低（优势比= 0.56,P = 0.0006）。非同义SNP rs5063 （P . val32met）似乎与ANP水平相关（P = 0.0209）。eQTL分析发现，rs198358在睾丸（1.66 × 10-9）和全血（4.58 × 10-52）中与NPPA基因表达相关。研究结果表明，一个常见的NPPA snp rs5063与血清ANP水平相关，ANP与中国汉族人群的高血压有潜在的相关性。
The natriuretic peptide system plays an important role in regulation of blood pressure. The purpose of this study was to comprehensively examine the associations among NPPA gene SNPs, serum atrial natriuretic peptide (ANP) levels, and hypertension. In 736 new-onset hypertensive cases and 736 age- and sex-matched controls, we measured concentrations of serum NT-proANP and genotyped 3 tag-SNPs in NPPA. Serum ANP levels were significantly lower in hypertensive patients than in controls (Wilcoxon two sample test P = 0.011). The difference was also significant in male (P = 0.0161) and female subgroups (P = 0.0011). Compared with the reference group, participants with the highest quartile of ANP levels had a significant decreased risk of hypertension (odds ratio = 0.56, P = 0.0006). The nonsynonymous SNP rs5063 (p.Val32Met) seemed to be associated with ANP levels (P = 0.0209). eQTL analysis found that rs198358 was associated with NPPA gene expression in testis (1.66 × 10-9) and whole blood (4.58 × 10-52). The findings suggested that a common NPPA SNPs rs5063 was associated with serum ANP levels and ANP was prospectively associated with hypertension in the Chinese Han population.
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DOI：
10.1016/b978-0-12-818460-8.00021-6
发表时间：
2020
期刊：
Present Knowledge in Nutrition
影响因子：
--
作者：
T. Sanders
通讯作者：
T. Sanders
DOI：
10.1161/circgenetics.117.001713
发表时间：
2017-12
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Salo PP;Havulinna AS;Tukiainen T;Raitakari O;Lehtimäki T;Kähönen M;Kettunen J;Männikkö M;Eriksson JG;Jula A;Blankenberg S;Zeller T;Salomaa V;Kristiansson K;Perola M
通讯作者：
Perola M
影响因子：
14.9
作者：
Kheradpour P;Kellis M
通讯作者：
Kellis M
PhosSNP 用于系统分析影响蛋白质磷酸化的遗传多态性
影响因子：
7
作者：
Ren, Jian;Jiang, Chunhui;Yao, Xuebiao
通讯作者：
Yao, Xuebiao
影响因子：
14.9
作者：
Ward LD;Kellis M
通讯作者：
Kellis M