Nationwide Epidemiological Survey of Autoimmune Pancreatitis in Japan in 2011
Nationwide Epidemiological Survey of Autoimmune Pancreatitis in Japan in 2011
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DOI：
10.1097/mpa.0000000000000325
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发表时间：
2015-05-01
期刊：
影响因子：
2.9
通讯作者：
Shimosegawa, Tooru
中科院分区：
文献类型：
--
作者：
Kanno, Atsushi;Masamune, Atsushi;Shimosegawa, Tooru
目的：为了阐明日本自身免疫性胰腺炎（AIP）的临床流行病学特征，在日本进行了一项全国性的流行病学调查。方法：对2011年在选定医院就诊的AIP患者进行调查。根据修订的AIP临床诊断标准（日本胰腺学会2011）诊断自身免疫性胰腺炎。结果：2011年中国AIP患者总数为5745例（95%可信区间5325-6164），总患病率为4.6/10万。新诊断为AIP的患者数量估计为1808例（95%置信区间，1597-2018），年发病率为1.4/10万人口。性别比（男性对女性）为3.2，平均年龄为66.3岁（11.5岁）。在936例患者的详细的临床资料，86.4%的患者出现高血清免疫球蛋白G4水平（>= 135 mg/dL），82.3%接受类固醇therapy.Conclusions：数据代表了目前的临床特点AIP在日本。
Objectives: To clarify the clinicoepidemiological features of autoimmune pancreatitis (AIP) in Japan, a nationwide epidemiological survey was conducted.Methods: Patients with AIP who had visited selected hospitals in 2011 were surveyed. Autoimmune pancreatitis was diagnosed according to the revised clinical diagnostic criteria for AIP (Japan Pancreas Society 2011). The study consisted of 2 stage surveys; the number of patients with AIP was estimated by the first questionnaire, and their clinical features were assessed by the second questionnaire.Results: The estimated total number of AIP patients in 2011 was 5745 (95% confidence interval, 5325-6164), with an overall prevalence rate of 4.6 per 100,000 population. The number of patients who were newly diagnosed as AIP was estimated to be 1808 (95% confidence interval, 1597-2018), with an annual incidence rate of 1.4 per 100,000 population. The sex ratio (male to female) was 3.2, and the mean age was 66.3 (11.5). Among the 936 patients whose detailed clinical information was obtained, 86.4% of the patients presented high serum immunoglobulin G4 levels (>= 135 mg/dL), and 82.3% received steroid therapy.Conclusions: The data represent the current clinical features of AIP in Japan.