Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer.
Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer.
复制标题
DOI：
10.4103/1008-682x.126400
复制
发表时间：
2014-05
影响因子：
2.9
通讯作者：
Hahn NM
中科院分区：
文献类型：
--
作者：
Albany C;Hahn NM
细胞凋亡途径中的缺陷与前列腺癌（PCa）肿瘤发生、转移进展和治疗抗性有关。癌症的标志是通过抑制细胞凋亡信号、减少细胞凋亡蛋白的表达和/或通过增加抗细胞凋亡分子的产生来放大存活信号而使细胞凋亡脱轨的能力。本文综述了热休克蛋白（HSPs）和人类雄激素受体（AR）之间的关联，热休克蛋白和其他应激诱导蛋白在前列腺癌发展中的作用，以及针对这些保护性蛋白治疗前列腺癌的新策略。
Defects within apoptotic pathways have been implicated in prostate cancer (PCa) tumorigenesis, metastatic progression and treatment resistance. A hallmark of cancers is the ability to derail apoptosis by inhibiting the apoptotic signal, reducing the expression of apoptotic proteins and/or amplifying survival signals through increased production of antiapoptotic molecule. This review describes associations between heat shock proteins (HSPs) and the human androgen receptor (AR), the role of HSPs and other stress-induced proteins in PCa development and emerging strategies in targeting these protective proteins to treat PCa.