Impact of obesity on cardiac metabolism, fibrosis, and function
Impact of obesity on cardiac metabolism, fibrosis, and function
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DOI：
10.1016/j.tcm.2014.09.005
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发表时间：
2015-02-01
影响因子：
9.3
通讯作者：
Sanders, Prashanthan
中科院分区：
文献类型：
--
作者：
Mahajan, Rajiv;Lau, Dennis H.;Sanders, Prashanthan
肥胖是一种全球性流行病，给医疗保健系统带来巨大负担。肥胖不仅与动脉粥样硬化性血管疾病的危险因素的发展有关，而且与心室肥大、心力衰竭、心房颤动和中风密切相关。最近的实验和临床研究表明，肥胖与心功能障碍、脂肪因子失调和导致心脏纤维化的促纤维化信号通路的激活相关，心脏纤维化是导致心房颤动的关键结构变化。重要的是，这些也被证明是可逆的减肥策略。本文综述了肥胖对心脏代谢和功能的影响。此外，它解决了复杂的，尚未完全理解的机制，心脏纤维化，重点是心房基质诱发房颤的肥胖。皇冠版权所有（C）2015由Elsevier Inc.发布。All rights reserved.
Obesity is a global pandemic with a huge burden on the healthcare system. Obesity is not only linked to the development of risk factors for atherosclerotic vascular disease but also has a strong association with ventricular hypertrophy, heart failure, atrial fibrillation, and stroke. Recent experimental and clinical studies have demonstrated that obesity is associated with cardiac dysfunction, adipokine dysregulation, and activation of the pro-fibrotic signaling pathways leading to cardiac fibrosis, which is a key structural change responsible for atrial fibrillation. Importantly, these also have been shown to be reversible with weight reduction strategies. This review discusses the alterations in cardiac metabolism and function due to obesity. In addition, it addresses the complex and not yet fully understood mechanisms underlying cardiac fibrosis, with a focus on atrial substrate predisposing to atrial fibrillation in obesity. Crown Copyright (C) 2015 Published by Elsevier Inc. All rights reserved.