Endometrial thickness influences neonatal birth weight in pregnancies with obstetric complications achieved after fresh IVF-ICSI cycles
Endometrial thickness influences neonatal birth weight in pregnancies with obstetric complications achieved after fresh IVF-ICSI cycles
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DOI：
10.1007/s00404-017-4411-z
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发表时间：
2017-07-01
影响因子：
2.6
通讯作者：
De Geyter, Christian
中科院分区：
文献类型：
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作者：
Moffat, Rebecca;Beutler, Sjanneke;De Geyter, Christian
妊娠相关并发症、妊娠期和产次是众所周知的新生儿出生体重的预测因素。辅助生殖技术（ART）也会影响新生儿出生体重。本文回顾性分析了1997年11月至2014年11月间764例单胎初产妇的资料，分析了子宫内膜厚度与母婴特征的关系，并探讨了子宫内膜厚度对新生儿出生体重的预测价值。母亲年龄（p < 0.001）、卵巢储备功能下降（p < 0.001）、子宫内膜异位症（p = 0.008）和低促性腺激素性功能减退症（p < 0.001）预示子宫内膜薄。新生儿出生体重（p = 0.004）、妊娠时间较长（p = 0.008）、产次（p = 0.026）和母亲BMI较高（p = 0.003）与子宫内膜增生程度显著相关。子宫内膜厚度强烈预测新生儿出生体重（p = 0.004）。在对母亲年龄和BMI、产次、新生儿性别和妊娠持续时间进行校正回归分析后，子宫内膜厚度仍然是产科并发症孕妇新生儿出生体重的预测指标（p = 0.017）。在顺利妊娠中，妊娠期和产次是新生儿出生体重的决定因素，我们的研究结果表明子宫内膜厚度是影响新生儿出生体重的另一个ART相关因素。这一发现应在大型队列研究中得到证实。
Pregnancy-associated complications, duration of gestation and parity are well-known predictors of neonatal birth weight. Assisted reproductive technology (ART) affects neonatal birth weight as well. Endometrial thickness as measured on the day of HCG triggering may therefore impact on the neonatal birth weight.The data of 764 singleton deliveries achieved after fresh transfer between November 1997 and 2014 were collected retrospectively with the intention to analyze the relationship of maternal and neonatal characteristics with endometrial thickness and the possible predictive value of endometrial thickness on neonatal birth weight.Higher maternal age (p < 0.001), diminished ovarian reserve (p < 0.001), endometriosis (p = 0.008) and hypogonadotropic hypogonadism (p < 0.001) predicted thin endometrium. Neonatal birth weight (p = 0.004), longer duration of pregnancy (p = 0.008), parity (p = 0.026) and higher maternal BMI (p = 0.003) were correlated significantly with the degree of endometrial proliferation. Endometrial thickness strongly predicted neonatal birth weight (p = 0.004). After adjusting regression analysis for maternal age and BMI, parity, neonatal gender and pregnancy duration, endometrial thickness remained predictive for neonatal birth weight in pregnancies with obstetric complications (p = 0.017). In uneventful pregnancies duration and parity are determinants of neonatal birth weight.Our findings suggest that endometrial thickness is an additional ART-related factor influencing neonatal birth weight. This finding should be confirmed in large cohort studies.