A FACTOR CAPABLE OF INCREASING VASCULAR PERMEABILITY PRESENT IN LYMPH NODE CELLS. A POSSIBLE MEDIATOR OF THE DELAYED REACTION.
A FACTOR CAPABLE OF INCREASING VASCULAR PERMEABILITY PRESENT IN LYMPH NODE CELLS. A POSSIBLE MEDIATOR OF THE DELAYED REACTION.
复制标题
一种能够增加淋巴结细胞中血管通透性的因子。
作者：
D. Willoughby;B. Boughton;H. Schild
从豚鼠淋巴结细胞（LPF）中提取的可溶性提取物已被发现可以增加大鼠皮肤的血管通透性。通过平行定量分析，从大鼠和豚鼠血清中分离出组胺、5-羟色胺、缓激肽、P物质、钾激肽和球蛋白通透性因子。LPF存在于致敏和非致敏的豚鼠淋巴结细胞以及大鼠和小鼠的淋巴结细胞中。LPF还能增加豚鼠、小鼠和家兔皮肤的血管通透性。讨论了这一因素在延迟反应机理中的重要性。
A soluble extract from guinea-pig lymph node cells (LPF) has been found to increase vascular permeability in the skin of the rat. The active substance has been differentiated from histamine, 5-hydroxytryptamine, bradykinin, substance P, kallikrein and the globulin permeability factors from rat and guinea-pig serum by means of parallel quantitative assays. LPF was present in both sensitized and non-sensitized guinea-pig lymph node cells and in lymph node cells from rats and mice. LPF also increased vascular permeability in the skin of guinea-pigs, mice and rabbits. The possible importance of this factor in the mechanism of the delayed reactions is discussed.