HERITABILITY OF VARIATION OF PLASMA-CORTISOL LEVELS
HERITABILITY OF VARIATION OF PLASMA-CORTISOL LEVELS
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DOI：
10.1016/0026-0495(88)90164-3
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发表时间：
1988-06-01
影响因子：
9.8
通讯作者：
BISHOP, DT
中科院分区：
文献类型：
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作者：
MEIKLE, AW;STRINGHAM, JD;BISHOP, DT
本文研究了20对同卵双生子(MZ)双生子(DZ)血浆总皮质醇、游离皮质醇、结合球蛋白(CBG)和硫酸脱氢表雄酮(DHEA-S)浓度变化的遗传度。在上午8点至9：30之间采集三份血浆样本，用于检测。遗传力由组内相关[2(RMZ-RDZ)]计算。双生子MZ组和DZ组的平均年龄、总皮质醇、游离皮质醇、脑血糖值和脱氢表雄酮-S无显著差异。血浆类固醇含量变异遗传力指数：总皮质醇45.4%(P<；0.05)，游离血浆皮质醇50.6%(P<；0.05)，脱氢表雄酮-S 57.8%(P<；0.05)，CBG 32.4%(P>；0.05)。通过因子分析对数据进行分析，并对双胞胎中的因子荷尔蒙的遗传力估计进行了修正。对皮质醇、游离皮质醇百分比和脱氢表雄酮-S这三个定量测量指标的因子分析，没有提供共享因子的证据。年龄、CBG、血浆总皮质醇浓度和游离皮质醇浓度的相关系数均不显著。血浆总皮质醇水平与CBG的相关系数为0.57，说明CBG对血浆皮质醇浓度变化的贡献率为32%。结果表明，遗传因素对正常成年男性脱氢表雄酮-S皮质醇浓度的变化有一定影响。
Heritability of the variation of the plasma concentrations of total and unbound cortisol, binding globulin (CBG), and dehydroepiandrosterone sulfate (DHEA-S) was investigated in 20 monozygotic (MZ) dizgotic (DZ) male twin pairs. Three plasma samples collected between 8 AM and 9:30 AM were pooled for the assays. Hertiability was calculated from the intraclass correlation [2(rMZ - rDZ)]. The mean age, total and unbound cortisol, CBG, and DHEA-S were not significantly different between the MZ and DZ groups of twins. The hertiability index for variability of the plasma content of steroids was 45.4% (p < .05) for total cortisol, 50.6% (P < .05) for unbound plasma cortisol, 57.8% (P < .05) for DHEA-S, and 32.4% (P > .05) for CBG. The data were analyzed by factor analysis, and hertability estimates were corrected for factors hormone values in twin pairs. Factor analysis of the three quantative measurements, cortisol, percent free cortisol, and DHEA-S, provides no evidence for shared factors. The correlation coefficients age and CBG and total and unbound plasma cortisol concentrations were insignificant. The correlation coefficent between total plasma cortisol levels and CBG was 0.57, which indicates that CBG accounts for 32% of the variation of plasma cortisol concentrations. The results suggest that genetic factors have a decided influence on the variation of the concentration of cortisol of DHEA-S in normal adult men.