DNA damage and biological responses induced by Boron Neutron Capture Therapy (BNCT).
DNA damage and biological responses induced by Boron Neutron Capture Therapy (BNCT).
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DOI：
10.1016/bs.enz.2022.08.005
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发表时间：
2022-01-01
期刊：
影响因子：
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通讯作者：
Kondo, Natsuko
中科院分区：
文献类型：
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作者：
Kondo, Natsuko
硼中子俘获疗法（BNCT）是一种肿瘤细胞选择性高LET（线性能量转移）粒子束疗法。患者通过静脉注射或输注硼（10B）化合物，当10B在肿瘤中充分积累时，以超热中子为主要成分的中子束照射。超热中子在体内失去能量，变成热中子。捕获的10B与热中子发生a （n, α）反应，生成的α粒子和7Li原子核的距离较短，分别为9-10mum和4-5mum，在正常组织中不能到达周围细胞。因此，这些高let -重带电粒子可以选择性地杀死癌细胞。这些重带电粒子的细胞杀伤作用被认为是由DNA损伤引发的。众所周知，重带电粒子造成的DNA损伤比低LET辐射（如x射线和伽马射线）造成的DNA损伤更为严重和难以修复。本文综述了BNCT引起的DNA损伤，如DNA链断裂和DNA损伤修复，并描述了由此产生的生物反应。
Boron Neutron Capture Therapy (BNCT) is a tumor cell selective high LET (linear energy transfer) particle beam therapy. The patient is administrated a boron (10B) compound via intravenous injection or infusion, and when 10B is sufficiently accumulated in the tumor, neutron beams containing epithermal neutrons as the main component are irradiated. Epithermal neutrons lose energy in the body and become thermal neutrons. The captured 10B undergoes a (n, alpha) reaction with thermal neutrons, and the resulting alpha particles and 7Li nuclei have short ranges of 9-10mum and 4-5mum, respectively, and do not reach the surrounding cells in normal tissues. Therefore, these high LET-heavy charged particles can selectively kill cancer cells. The cell-killing effect of these heavy charged particles is thought to be triggered by DNA damage. It is known that DNA damage caused by heavy charged particles is more serious and difficult to repair than DNA damage caused by Low LET radiation such as X-rays and gamma-rays. This review focuses on DNA damage, e.g., DNA strand breaks and DNA damage repair caused by BNCT and describes the resulting biological response.