Recommendations for prevention of and therapy for exposure to B virus (Cercopithecine herpesvirus 1)
Recommendations for prevention of and therapy for exposure to B virus (Cercopithecine herpesvirus 1)
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DOI：
10.1086/344754
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发表时间：
2002-11-15
影响因子：
11.8
通讯作者：
Chapman, LE
中科院分区：
文献类型：
--
作者：
Cohen, JI;Davenport, DS;Chapman, LE
B病毒（1型长尾猴疱疹病毒）是一种人畜共患病原体，可导致人类致命性脑脊髓炎。该病毒自然感染猕猴，导致类似于人类单纯疱疹病毒感染的疾病。尽管猕猴的B病毒感染通常无症状或轻微，但对人类来说可能是致命的。以前报告的人类B病毒病病例通常归因于动物咬伤、抓伤或经皮接种受感染材料;然而，1998年报告了由于粘膜飞溅暴露导致的首例B病毒感染致死病例。这一病例促使疾病控制和预防中心（格鲁吉亚亚特兰大）于1999年召集了一个工作组，重新考虑先前关于预防和治疗B病毒暴露的建议。本报告更新了以前对预防、评价和治疗人类B病毒感染的建议，并考虑了新的抗病毒药物在暴露后预防中的作用。
B virus (Cercopithecine herpesvirus 1) is a zoonotic agent that can cause fatal encephalomyelitis in humans. The virus naturally infects macaque monkeys, resulting in disease that is similar to herpes simplex virus infection in humans. Although B virus infection generally is asymptomatic or mild in macaques, it can be fatal in humans. Previously reported cases of B virus disease in humans usually have been attributed to animal bites, scratches, or percutaneous inoculation with infected materials; however, the first fatal case of B virus infection due to mucosal splash exposure was reported in 1998. This case prompted the Centers for Disease Control and Prevention (Atlanta, Georgia) to convene a working group in 1999 to reconsider the prior recommendations for prevention and treatment of B virus exposure. The present report updates previous recommendations for the prevention, evaluation, and treatment of B virus infection in humans and considers the role of newer antiviral agents in postexposure prophylaxis.