Sensitivity of differentPseudomonas species andAeromonas hydrophila to trimethoprim and sulfamethoxazole separately and in combination
Sensitivity of differentPseudomonas species andAeromonas hydrophila to trimethoprim and sulfamethoxazole separately and in combination
复制标题
不同假单胞菌和嗜水气单胞菌对甲氧苄啶和磺胺甲恶唑单独和联合用药的敏感性
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
B. Wretlind
中科院分区：
文献类型：
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作者：
C. Nord;T. Wadström;B. Wretlind
采用琼脂稀释法测定不同假单胞菌属和嗜水气单胞菌对甲氧苄啶、磺胺甲恶唑以及这些药物保持1:20比例的组合的体外敏感性。荧光假单胞菌（铜绿假单胞菌、恶臭假单胞菌、荧光假单胞菌）普遍对单独用药和联合用药产生耐药性。对于其他假单胞菌属物种，分离菌株对药物的敏感性各不相同，并且发现大约一半菌株的组合具有协同效应。嗜水气单胞菌通常对两种药物敏感，并且发现组合的协同效应比假单胞菌更强。
An agar dilution method was used to determine thein vitro sensitivity of differentPseudomonas species andAeromonas hydrophila to trimethoprim, sulfamethoxazole, and a combination of these drugs maintaining a ratio of one to twenty. The fluorescent pseudomonads (Pseudomonas aeruginosa, P. putida, andP. fluorescens) were generally resistant to the drugs separately and combined. For otherPseudomonas species the sensitivity of the isolated strains to the drugs were variable and a synergistic effect of the combination was found for about half of the strains.Aeromonas hydrophila was generally sensitive to both drugs and a stronger synergistic effect of the combination was found than for the pseudomonads.