Activation of neurotransplants in humans
Activation of neurotransplants in humans
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DOI：
10.1006/exnr.1999.7073
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发表时间：
1999-07-01
影响因子：
5.3
通讯作者：
Ross, BD
中科院分区：
文献类型：
--
作者：
Blüml, S;Kopyov, O;Ross, BD
临床研究报告大多数胎儿神经移植治疗帕金森病患者的症状获益。潜在的机制还没有完全解释清楚。我们研究了宿主和移植组织之间是否建立了神经连接。对2例临床预后良好的帕金森病患者进行了功能磁共振成像研究。重复性运动任务在志愿者的对侧壳核中提供了强大的刺激，激活了患者的壳核移植物承载区域。在对侧运动任务的反应中，患者1的左壳核和患者2的右壳核一致被激活。功能磁共振成像表明，神经元重新布线有助于神经移植在人体体内的功能。(C) 1999学术出版社。
Clinical studies report symptomatic benefit in most fetal neurotransplantation treated Parkinson's disease patients. The underlying mechanism is incompletely explained. We investigated whether neural connections between host and transplanted tissue are established. Two Parkinson's disease patients with clinically excellent outcome after transplantation were studied with functional magnetic resonance imaging. A repetitive motor task that provided robust stimulation in the contralateral putamen in volunteers activated graft bearing regions of putamen in patients. In response to contralateral motor tasks, activation was recorded consistently in left putamen in patient 1 and in right putamen in patient 2. Functional magnetic resonance imaging suggests that neuronal rewiring contributes to the functioning of neurotransplants in vivo in humans. (C) 1999 Academic Press.