Relationship between disease duration and predominant orbital T cell subset in Graves' ophthalmopathy
Relationship between disease duration and predominant orbital T cell subset in Graves' ophthalmopathy
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DOI：
10.1210/jc.85.2.776
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发表时间：
2000-02-01
影响因子：
5.8
通讯作者：
Bahn, RS
中科院分区：
文献类型：
--
作者：
Aniszewski, JP;Valyasevi, RW;Bahn, RS
我们试图确定从Graves眼病（GO）患者建立的眼眶T细胞克隆中占优势的眼眶T辅助（T1）细胞亚群是否与疾病持续时间有关。从6名GO患者的眼眶脂肪/结缔组织中建立了总共117个克隆，并在57个CD 3（+）CD 4（+）克隆中测量了细胞因子的产生。T（H）1型克隆在近期发病患者的培养物中占主导地位（
We sought to determine whether the predominant orbital T helper (T,) cell subset in orbital T cell clones established from patients with Graves' ophthalmopathy (GO) might be related to disease duration. A total of 117 clones were established from orbital adipose/connective tissues of 6 GO patients, and cytokine production was measured in 57 CD3(+)CD4(+) clones. T(H)1-type clones were predominant in cultures from patients with recent onset (