NEURONAL ANTINUCLEAR ANTIBODY (ANTI-HU) IN PARA-NEOPLASTIC ENCEPHALOMYELITIS SIMULATING ACUTE POLYNEURITIS
NEURONAL ANTINUCLEAR ANTIBODY (ANTI-HU) IN PARA-NEOPLASTIC ENCEPHALOMYELITIS SIMULATING ACUTE POLYNEURITIS
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DOI：
10.1111/j.1600-0404.1987.tb07928.x
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发表时间：
1987-04-01
影响因子：
3.5
通讯作者：
AGUSTIVIDAL, A
中科院分区：
文献类型：
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作者：
GRAUS, F;ELKON, KB;AGUSTIVIDAL, A
一名患有副肿瘤性脑脊髓炎（PEM）和小细胞肺癌的患者临床表现为急性多发性神经炎。该患者的抗体（抗Hu）局限于神经元核，与亚急性感觉神经元病和肺癌患者报告的抗体相同。这一发现进一步支持了PEM和亚急性感觉神经元病是密切相关的自身免疫性疾病的假设。小细胞肺癌和临床特征仅限于周围神经系统的患者应考虑PEM。
A patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer had a clinical presentation of acute polyneuritis. The patient had an antibody (anti-Hu) resticted to nuclei of neurons identical to that reported in patients with subacute sensory neuronopathy and lung cancer. This finding further supports the hypothesis that PEM and subacute sensory neuronopathy are closely related disorders of autoimmune origin. PEM should be considered in patients with small cell lung cancer and clinical features limited to the peripheral nervous system.